Targeting the Spike Receptor Binding Domain Class V Cryptic Epitope by an Antibody with Pan-Sarbecovirus Activity

Novel therapeutic monoclonal antibodies (MAbs) must accommodate comprehensive breadth of activity against diverse sarbecoviruses and high neutralization potency to overcome emerging variants. Here, we report the crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) re...

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Detalles Bibliográficos
Autores principales: Jensen, Jaime L., Sankhala, Rajeshwer S., Dussupt, Vincent, Bai, Hongjun, Hajduczki, Agnes, Lal, Kerri G., Chang, William C., Martinez, Elizabeth J., Peterson, Caroline E., Golub, Emily S., Rees, Phyllis A., Mendez-Rivera, Letzibeth, Zemil, Michelle, Kavusak, Erin, Mayer, Sandra V., Wieczorek, Lindsay, Kannan, Shruthi, Doranz, Benjamin J., Davidson, Edgar, Yang, Eun Sung, Zhang, Yi, Chen, Man, Choe, Misook, Wang, Lingshu, Gromowski, Gregory D., Koup, Richard A., Michael, Nelson L., Polonis, Victoria R., Rolland, Morgane, Modjarrad, Kayvon, Krebs, Shelly J., Joyce, M. Gordon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373542/
https://www.ncbi.nlm.nih.gov/pubmed/37395646
http://dx.doi.org/10.1128/jvi.01596-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373542/
https://www.ncbi.nlm.nih.gov/pubmed/37395646
http://dx.doi.org/10.1128/jvi.01596-22

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