Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment

BACKGROUND: Interactions between immune and tumor cells are critical to determining cancer progression and response. In addition, preclinical prediction of immune-related drug efficacy is limited by interspecies differences between human and mouse, as well as inter-person germline and somatic variat...

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Detalles Bibliográficos
Autores principales: Chiorazzi, Michael, Martinek, Jan, Krasnick, Bradley, Zheng, Yunjiang, Robbins, Keenan J, Qu, Rihao, Kaufmann, Gabriel, Skidmore, Zachary, Juric, Melani, Henze, Laura A, Brösecke, Frederic, Adonyi, Adam, Zhao, Jun, Shan, Liang, Sefik, Esen, Mudd, Jacqueline, Bi, Ye, Goedegebuure, S Peter, Griffith, Malachi, Griffith, Obi, Oyedeji, Abimbola, Fertuzinhos, Sofia, Garcia-Milian, Rolando, Boffa, Daniel, Detterbeck, Frank, Dhanasopon, Andrew, Blasberg, Justin, Judson, Benjamin, Gettinger, Scott, Politi, Katerina, Kluger, Yuval, Palucka, Karolina, Fields, Ryan C, Flavell, Richard A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373695/
https://www.ncbi.nlm.nih.gov/pubmed/37487666
http://dx.doi.org/10.1136/jitc-2023-006921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373695/
https://www.ncbi.nlm.nih.gov/pubmed/37487666
http://dx.doi.org/10.1136/jitc-2023-006921

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