The AKT inhibitor, MK-2206, attenuates ABCG2-mediated drug resistance in lung and colon cancer cells

Introduction: The overexpression of ATP-binding cassette (ABC) transporters, ABCB1 and ABCG2, are two of the major mediators of multidrug resistance (MDR) in cancers. Although multiple ABCB1 and ABCG2 inhibitors have been developed and some have undergone evaluation in clinical trials, none have bee...

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Detalles Bibliográficos
Autores principales: Gao, Hai-Ling, Cui, Qingbin, Wang, Jing-Quan, Ashby, Charles R., Chen, Yanchun, Shen, Zhi-Xin, Chen, Zhe-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373739/
https://www.ncbi.nlm.nih.gov/pubmed/37521473
http://dx.doi.org/10.3389/fphar.2023.1235285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373739/
https://www.ncbi.nlm.nih.gov/pubmed/37521473
http://dx.doi.org/10.3389/fphar.2023.1235285

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