Cargando…

Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice

Alzheimer’s disease (AD) poses a significant threat to the global elderly population. Traditional Chinese medicine (TCM) has been widely utilized in the treatment of AD. Osthole, a bioactive ingredient classified as an “emperor” in many TCM formulas, has been demonstrated to effectively alleviate AD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Fanchang, Huang, Mingjun, Zuo, Xue, Xie, Ruiye, Liu, Jinman, Ke, Junyu, Li, Weirong, Wang, Qi, Liang, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373789/ https://www.ncbi.nlm.nih.gov/pubmed/37521471 http://dx.doi.org/10.3389/fphar.2023.1224856

Ejemplares similares

Development of Carbamazepine Nanostructured Lipid Carrier Loaded Thermosensitive Gel for Intranasal Delivery
por: Deshkar, Sanjeevani Shekhar, et al.
Publicado: (2021)

Clozapine-Encapsulated Binary Mixed Micelles in Thermosensitive Sol–Gels for Intranasal Administration
por: Tan, Madeleine S. A., et al.
Publicado: (2022)

Development of a Cyclodextrin-Based Mucoadhesive-Thermosensitive In Situ Gel for Clonazepam Intranasal Delivery
por: Cirri, Marzia, et al.
Publicado: (2021)

Superiority of TPGS-loaded micelles in the brain delivery of vinpocetine via administration of thermosensitive intranasal gel
por: Ahmed, Tarek A, et al.
Publicado: (2019)

Curcumin Transferosome-Loaded Thermosensitive Intranasal in situ Gel as Prospective Antiviral Therapy for SARS-Cov-2
por: Eleraky, Nermin E, et al.
Publicado: (2023)

Development and Evaluation of Stability of a Gel Formulation Containing the Monoterpene Borneol
por: Dantas, Milla Gabriela Belarmino, et al.
Publicado: (2016)

Lincomycin HCl-Loaded Borneol-Based In Situ Gel for Periodontitis Treatment
por: Puyathorn, Napaphol, et al.
Publicado: (2023)

Intranasal delivery of Clozapine using nanoemulsion-based in-situ gels: An approach for bioavailability enhancement
por: Abdulla, Nourhan A., et al.
Publicado: (2021)

Bioavailability and Brain-Targeting of Geniposide in Gardenia-Borneol Co-Compound by Different Administration Routes in Mice
por: Lu, Yang, et al.
Publicado: (2012)

Enhancing both oral bioavailability and brain penetration of puerarin using borneol in combination with preparation technologies
por: Yi, Tao, et al.
Publicado: (2017)

Osthole-Loaded Nanoemulsion Enhances Brain Target in the Treatment of Alzheimer's Disease via Intranasal Administration
por: Song, Yilei, et al.
Publicado: (2021)

Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson’s disease
por: Tang, Shengnan, et al.
Publicado: (2019)

Evaluation of the analgesic potential and safety of Cinnamomum camphora chvar. Borneol essential oil
por: Xiao, Shanshan, et al.
Publicado: (2021)

Phase Inversion-Based Doxycycline Hyclate-Incorporated Borneol In Situ Gel for Periodontitis Treatment
por: Lertsuphotvanit, Nutdanai, et al.
Publicado: (2023)

Intranasal Administration of Dolutegravir-Loaded Nanoemulsion-Based In Situ Gel for Enhanced Bioavailability and Direct Brain Targeting
por: Nair, Anroop B., et al.
Publicado: (2023)

Intranasal BMP9 Ameliorates Alzheimer Disease-Like Pathology and Cognitive Deficits in APP/PS1 Transgenic Mice
por: Wang, Zigao, et al.
Publicado: (2017)

Clotrimazole-Loaded Borneol-Based In Situ Forming Gel as Oral Sprays for Oropharyngeal Candidiasis Therapy
por: Lertsuphotvanit, Nutdanai, et al.
Publicado: (2023)

Antimicrobial activity and the mechanism of silver nanoparticle thermosensitive gel
por: Chen, Meiwan, et al.
Publicado: (2011)

An Overview on Thermosensitive Oral Gel Based on Poloxamer 407
por: Chen, Yabing, et al.
Publicado: (2021)

Effects of intranasal dantrolene nanoparticles on brain concentration and behavior in PS19 tau transgenic mice
por: Vera, Robert, et al.
Publicado: (2023)

Evaluation of a novel oxiconazole nitrate formulation: The thermosensitive gel
por: Arslan, Alper, et al.
Publicado: (2018)

Disulfiram thermosensitive in-situ gel based on solid dispersion for cataract()
por: Zhang, Chunjuan, et al.
Publicado: (2018)

The evolution of borneol repellency in culicine mosquitoes
por: Vainer, Yuri, et al.
Publicado: (2023)

Anti-Leishmania Activity of Osthole
por: Kermani, Elaheh Kordzadeh, et al.
Publicado: (2016)

Design, characterization and comparison of transdermal delivery of colchicine via borneol-chemically-modified and borneol-physically-modified ethosome
por: Zhang, Yujia, et al.
Publicado: (2019)

Osthole Stimulated Neural Stem Cells Differentiation into Neurons in an Alzheimer's Disease Cell Model via Upregulation of MicroRNA-9 and Rescued the Functional Impairment of Hippocampal Neurons in APP/PS1 Transgenic Mice
por: Li, Shao-Heng, et al.
Publicado: (2017)

Rational Design of Thermosensitive Hydrogel to Deliver Nanocrystals with Intranasal Administration for Brain Targeting in Parkinson's Disease
por: Tan, Yun, et al.
Publicado: (2021)

Transferrin-Modified Osthole PEGylated Liposomes Travel the Blood-Brain Barrier and Mitigate Alzheimer’s Disease-Related Pathology in APP/PS-1 Mice
por: Kong, Liang, et al.
Publicado: (2020)

Formulation of Thermosensitive in situ Otic Gel for Topical Management of Otitis Media
por: Shau, P. A., et al.
Publicado: (2015)

Thermosensitive Gels Used to Improve Microneedle-Assisted Transdermal Delivery of Naltrexone
por: Tobin, Kevin V., et al.
Publicado: (2021)

Particle and Gel Characterization of Irinotecan-Loaded Double-Reverse Thermosensitive Hydrogel
por: Din, Fakhar ud, et al.
Publicado: (2021)

Enhanced Bioavailability of Tadalafil after Intranasal Administration in Beagle Dogs
por: Kim, Jeong-Soo, et al.
Publicado: (2018)

Alginate nanogels-based thermosensitive hydrogel to improve antidepressant-like effects of albiflorin via intranasal delivery
por: Xu, Dong, et al.
Publicado: (2021)

Efficacy of Osthole in Management of Hypoperfused Retina
por: Du, Ran, et al.
Publicado: (2018)

Optimization and Evaluation of the Quercus infectoria Galls Thermosensitive In Situ Gel for Rectal Delivery
por: Arkin, Abdulaziz, et al.
Publicado: (2022)

Thermosensitive In Situ Gels for Joint Disorders: Pharmaceutical Considerations in Intra-Articular Delivery
por: Koland, Marina, et al.
Publicado: (2022)

Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice
por: Guo, Chuang, et al.
Publicado: (2015)

Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation
por: Fahmy, Usama A., et al.
Publicado: (2020)

Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation
por: Abou-Taleb, Heba A, et al.
Publicado: (2018)

The Role and Mechanism of Borneol to Open the Blood-Brain Barrier
por: Wu, Tao, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_p2sbrtsudi3tbqg44q2cq9sse6