Role of the mechanisms for antibody repertoire diversification in monoclonal light chain deposition disorders: when a friend becomes foe

The adaptive immune system of jawed vertebrates generates a highly diverse repertoire of antibodies to meet the antigenic challenges of a constantly evolving biological ecosystem. Most of the diversity is generated by two mechanisms: V(D)J gene recombination and somatic hypermutation (SHM). SHM intr...

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Detalles Bibliográficos
Autores principales: Del Pozo-Yauner, Luis, Herrera, Guillermo A., Perez Carreon, Julio I., Turbat-Herrera, Elba A., Rodriguez-Alvarez, Francisco J., Ruiz Zamora, Robin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374031/
https://www.ncbi.nlm.nih.gov/pubmed/37520549
http://dx.doi.org/10.3389/fimmu.2023.1203425

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374031/
https://www.ncbi.nlm.nih.gov/pubmed/37520549
http://dx.doi.org/10.3389/fimmu.2023.1203425

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