Engineering activatable promoters for scalable and multi-input CRISPRa/i circuits

Dynamic, multi-input gene regulatory networks (GRNs) are ubiquitous in nature. Multilayer CRISPR-based genetic circuits hold great promise for building GRNs akin to those found in naturally occurring biological systems. We develop an approach for creating high-performing activatable promoters that c...

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Detalles Bibliográficos
Autores principales: Alba Burbano, Diego, Cardiff, Ryan A. L., Tickman, Benjamin I., Kiattisewee, Cholpisit, Maranas, Cassandra J., Zalatan, Jesse G., Carothers, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374173/
https://www.ncbi.nlm.nih.gov/pubmed/37463216
http://dx.doi.org/10.1073/pnas.2220358120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374173/
https://www.ncbi.nlm.nih.gov/pubmed/37463216
http://dx.doi.org/10.1073/pnas.2220358120

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