Sniper2L is a high-fidelity Cas9 variant with high activity

Although several high-fidelity SpCas9 variants have been reported, it has been observed that this increased specificity is associated with reduced on-target activity, limiting the applications of the high-fidelity variants when efficient genome editing is required. Here, we developed an improved ver...

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Detalles Bibliográficos
Autores principales: Kim, Young-hoon, Kim, Nahye, Okafor, Ikenna, Choi, Sungchul, Min, Seonwoo, Lee, Joonsun, Bae, Seung-Min, Choi, Keunwoo, Choi, Janice, Harihar, Vinayak, Kim, Youngho, Kim, Jin-Soo, Kleinstiver, Benjamin P., Lee, Jungjoon K., Ha, Taekjip, Kim, Hyongbum Henry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374439/
https://www.ncbi.nlm.nih.gov/pubmed/36894722
http://dx.doi.org/10.1038/s41589-023-01279-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374439/
https://www.ncbi.nlm.nih.gov/pubmed/36894722
http://dx.doi.org/10.1038/s41589-023-01279-5

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