Cargando…

Exploring the Binding Mechanism of NRG1–ERBB3 Complex and Discovery of Potent Natural Products to Reduce Diabetes-Assisted Breast Cancer Progression

Diabetes mellitus significantly contributes to breast cancer progression, where hyperglycemia upregulates specific genes, leading to more aggressive tumor growth. In patients with BC that develop diabetes, neuregulin 1 (NRG1) and epidermal growth factor receptor 3 (ERBB3) overexpression exacerbate t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Marafie, Sulaiman K., Alshawaf, Eman, Abu-Farha, Mohamed, Thanaraj, Thangavel Alphonse, Wei, Dong-Qing, Al-Mulla, Fahd, Khan, Abbas, Abubaker, Jehad, Mohammad, Anwar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Nature Singapore 2023
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374477/ https://www.ncbi.nlm.nih.gov/pubmed/37389721 http://dx.doi.org/10.1007/s12539-023-00566-y

Ejemplares similares

Molecular Simulation-Based Investigation of Highly Potent Natural Products to Abrogate Formation of the nsp10–nsp16 Complex of SARS-CoV-2
por: Mohammad, Anwar, et al.
Publicado: (2021)

Higher binding affinity of furin for SARS-CoV-2 spike (S) protein D614G mutant could be associated with higher SARS-CoV-2 infectivity
por: Mohammad, Anwar, et al.
Publicado: (2021)

Structural analysis of ACE2 variant N720D demonstrates a higher binding affinity to TMPRSS2
por: Mohammad, Anwar, et al.
Publicado: (2020)

Discovery of natural products to block SARS-CoV-2 S-protein interaction with Neuropilin-1 receptor: A molecular dynamics simulation approach
por: Alshawaf, Eman, et al.
Publicado: (2022)

The Role of Lipid Metabolism in COVID-19 Virus Infection and as a Drug Target
por: Abu-Farha, Mohamed, et al.
Publicado: (2020)

The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19
por: Bosso, Mira, et al.
Publicado: (2020)

Targeting SARS-CoV-2 Macrodomain-1 to Restore the Innate Immune Response Using In Silico Screening of Medicinal Compounds and Free Energy Calculation Approaches
por: Mohammad, Anwar, et al.
Publicado: (2023)

A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations
por: Hebbar, Prashantha, et al.
Publicado: (2019)

Generalizability of GWA-Identified Genetic Risk Variants for Metabolic Traits to Populations from the Arabian Peninsula
por: Hebbar, Prashantha, et al.
Publicado: (2021)

FTO Variant rs1421085 Associates With Increased Body Weight, Soft Lean Mass, and Total Body Water Through Interaction With Ghrelin and Apolipoproteins in Arab Population
por: Hebbar, Prashantha, et al.
Publicado: (2020)

Impact of Diabetes in Patients Diagnosed With COVID-19
por: Abu-Farha, Mohamed, et al.
Publicado: (2020)

Targeted Metabolomics Analysis of Individuals Carrying the ANGPTL8 R59W Variant
por: Abu-Farha, Mohamed, et al.
Publicado: (2023)

The miR-668 binding site variant rs1046322 on WFS1 is associated with obesity in Southeast Asians
por: Hammad, Maha M., et al.
Publicado: (2023)

Single nucleotide polymorphisms in vitamin D binding protein and 25-hydroxylase genes affect vitamin D levels in adolescents of Arab ethnicity in Kuwait
por: Rahman, Abdur, et al.
Publicado: (2023)

Association of COVID-19 Vaccines ChAdOx1-S and BNT162b2 with Circulating Levels of Coagulation Factors and Antithrombin
por: Hasan, Amal, et al.
Publicado: (2022)

Investigating the Role of Myeloperoxidase and Angiopoietin-like Protein 6 in Obesity and Diabetes
por: Qaddoumi, Mohammad G., et al.
Publicado: (2020)

LRG1 Associates with Iron Deficiency Anemia Markers in Adolescents
por: Alhammad, Rashed, et al.
Publicado: (2023)

Increased Levels of Circulating IGFBP4 and ANGPTL8 with a Prospective Role in Diabetic Nephropathy
por: AlMajed, Hana Th., et al.
Publicado: (2023)

MC4R Variant rs17782313 Associates With Increased Levels of DNAJC27, Ghrelin, and Visfatin and Correlates With Obesity and Hypertension in a Kuwaiti Cohort
por: Hammad, Maha M., et al.
Publicado: (2020)

Relevance between COVID-19 and host genetics of immune response
por: Taher, Ibrahim, et al.
Publicado: (2021)

ACE2 and FURIN variants are potential predictors of SARS-CoV-2 outcome: A time to implement precision medicine against COVID-19
por: Al-Mulla, Fahd, et al.
Publicado: (2021)

ANGPTL3 Variants Associate with Lower Levels of Irisin and C-Peptide in a Cohort of Arab Individuals
por: Alanbaei, Muath, et al.
Publicado: (2021)

Increased LRG1 Levels in Overweight and Obese Adolescents and Its Association with Obesity Markers, Including Leptin, Chemerin, and High Sensitivity C-Reactive Protein
por: Alhammad, Rashed, et al.
Publicado: (2022)

GALNT2 rs4846914 SNP Is Associated with Obesity, Atherogenic Lipid Traits, and ANGPTL3 Plasma Level
por: Qaddoumi, Mohammad, et al.
Publicado: (2022)

Immunogenicity of BNT162b2 Vaccine in Patients with Inflammatory Bowel Disease on Infliximab Combination Therapy: A Multicenter Prospective Study
por: Shehab, Mohammad, et al.
Publicado: (2021)

The Rise of IGFBP4 in People with Obstructive Sleep Apnea and Multilevel Sleep Surgery Recovers Its Basal Levels
por: Alterki, Abdulmohsen, et al.
Publicado: (2021)

Prognostic Genetic Markers for Thrombosis in COVID-19 Patients: A Focused Analysis on D-Dimer, Homocysteine and Thromboembolism
por: Abu-Farha, Mohamed, et al.
Publicado: (2020)

Investigating the Relationship between Obstructive Sleep Apnoea, Inflammation and Cardio-Metabolic Diseases
por: Alterki, Abdulmohsen, et al.
Publicado: (2023)

Serological Response to BNT162b2 and ChAdOx1 nCoV-19 Vaccines in Patients with Inflammatory Bowel Disease on Biologic Therapies
por: Shehab, Mohammad, et al.
Publicado: (2021)

Caveolin-1 rs1997623 variant and adult metabolic syndrome—Assessing the association in three ethnic cohorts of Arabs, South Asians and South East Asians
por: Al Madhoun, Ashraf, et al.
Publicado: (2022)

Immunogenicity of BNT162b2 Vaccine Booster Dose in Patients With Inflammatory Bowel Disease Receiving Infliximab Combination Therapy: A Prospective Observational Study
por: Shehab, Mohammad, et al.
Publicado: (2022)

The Proinflammatory Role of ANGPTL8 R59W Variant in Modulating Inflammation through NF-κB Signaling Pathway under TNFα Stimulation
por: Abu-Farha, Mohamed, et al.
Publicado: (2023)

Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population
por: Hebbar, Prashantha, et al.
Publicado: (2020)

Targeted Metabolomics Analysis on Obstructive Sleep Apnea Patients after Multilevel Sleep Surgery
por: Alterki, Abdulmohsen, et al.
Publicado: (2020)

Editorial: Advances in the research of diabetic nephropathy, volume II
por: Iizuka, Katsumi, et al.
Publicado: (2023)

Editorial: Advances in the research of diabetic nephropathy
por: Abu-Farha, Mohamed, et al.
Publicado: (2023)

Frequency of functional exonic single-nucleotide polymorphisms and haplotype distribution in the SLCO1B1 gene across genetic ancestry groups in the Qatari population
por: Dashti, Mohammed, et al.
Publicado: (2022)

Association of significantly elevated plasma levels of NGAL and IGFBP4 in patients with diabetic nephropathy
por: Ali, Hamad, et al.
Publicado: (2022)

Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population
por: Hebbar, Prashantha, et al.
Publicado: (2020)

An Overview of the Role of Furin in Type 2 Diabetes
por: Marafie, Sulaiman K., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qth0vdn9svdo4bmk0gold3qb89