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Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity

BACKGROUND: Colorectal cancer (CRC) is one of the most prevalent diagnosed malignancies and one of the leading causes of cancer-related deaths worldwide. 5-Fluorouracil (5-FU) and its combination regimen are commonly used as primary chemotherapeutic agents for advanced CRC. Intestinal mucositis is o...

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Detalles Bibliográficos
Autores principales: Xia, Jing, Dai, Qian long, He, Siyue, Jia, Hui-jie, Liu, Xian-Guo, Hua, Hui, Zhou, Min, Wang, Xiaobo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374509/
https://www.ncbi.nlm.nih.gov/pubmed/37498338
http://dx.doi.org/10.1007/s12672-023-00747-7