Loss of TP53 cooperates with c-MET overexpression to drive hepatocarcinogenesis

Hepatocellular carcinoma (HCC) is a deadly malignancy with high genetic heterogeneity. TP53 mutation and c-MET activation are frequent events in human HCCs. Here, we discovered that the simultaneous mutations in TP53 and activation of c-MET occur in ~20% of human HCCs, and these patients show a poor...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Yi, Cui, Guofei, Xu, Hongwei, Chun, Joanne, Yang, Doris, Zhang, Zheng, Yang, Lihui, Wang, Jingxiao, Wan, Meijuan, Calvisi, Diego F., Lin, Shumei, Chen, Xin, Wang, Haichuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374654/
https://www.ncbi.nlm.nih.gov/pubmed/37500626
http://dx.doi.org/10.1038/s41419-023-05958-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374654/
https://www.ncbi.nlm.nih.gov/pubmed/37500626
http://dx.doi.org/10.1038/s41419-023-05958-y

Ejemplares similares