PME-1 sensitizes glioblastoma cells to oxidative stress-induced cell death by attenuating PP2A-B55α-mediated inactivation of MAPKAPK2-RIPK1 signaling

Glioblastoma (GBM) is the most common primary brain tumor in adults. Current standard therapy is surgery followed by radiotherapy, with concurrent and adjuvant temozolomide chemotherapy. GBM is characterized by almost uniformly fatal outcomes, highlighting the unmet clinical need for more efficient,...

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Detalles Bibliográficos
Autores principales: Guffens, Liesbeth, Derua, Rita, Janssens, Veerle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374899/
https://www.ncbi.nlm.nih.gov/pubmed/37500619
http://dx.doi.org/10.1038/s41420-023-01572-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374899/
https://www.ncbi.nlm.nih.gov/pubmed/37500619
http://dx.doi.org/10.1038/s41420-023-01572-1

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