In vivo and in vitro characterizations of melibiose permease (MelB) conformation-dependent nanobodies reveal sugar-binding mechanisms

Salmonella enterica serovar Typhimurium melibiose permease (MelB(St)) is a prototype of the Na(+)-coupled major facilitator superfamily transporters, which are important for the cellular uptake of molecules including sugars and small drugs. Although the symport mechanisms have been well-studied, mec...

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Detalles Bibliográficos
Autores principales: Katsube, Satoshi, Willibal, Katleen, Vemulapally, Sangama, Hariharan, Parameswaran, Tikhonova, Elena, Pardon, Els, Kaback, H. Ronald, Steyaert, Jan, Guan, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374971/
https://www.ncbi.nlm.nih.gov/pubmed/37380079
http://dx.doi.org/10.1016/j.jbc.2023.104967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374971/
https://www.ncbi.nlm.nih.gov/pubmed/37380079
http://dx.doi.org/10.1016/j.jbc.2023.104967

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