Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies

The human complement system plays a crucial role in immune defense. However, its erroneous activation contributes to many serious inflammatory diseases. Since most unwanted complement effector functions result from C5 cleavage into C5a and C5b, development of C5 inhibitors, such as clinically approv...

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Detalles Bibliográficos
Autores principales: Struijf, Eva M., De la O Becerra, Karla I., Ruyken, Maartje, de Haas, Carla J.C., van Oosterom, Fleur, Siere, Danique Y., van Keulen, Joanne E., Heesterbeek, Dani A.C., Dolk, Edward, Heukers, Raimond, Bardoel, Bart W., Gros, Piet, Rooijakkers, Suzan H.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374974/
https://www.ncbi.nlm.nih.gov/pubmed/37356719
http://dx.doi.org/10.1016/j.jbc.2023.104956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10374974/
https://www.ncbi.nlm.nih.gov/pubmed/37356719
http://dx.doi.org/10.1016/j.jbc.2023.104956

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