Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone

The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not fin...

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Autores principales: Stek, Cari, Shey, Muki, Mnika, Khuthala, Schutz, Charlotte, Thienemann, Friedrich, Wilkinson, Robert J, Lynen, Lutgarde, Meintjes, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375423/
https://www.ncbi.nlm.nih.gov/pubmed/37520416
http://dx.doi.org/10.1093/ofid/ofad379
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author Stek, Cari
Shey, Muki
Mnika, Khuthala
Schutz, Charlotte
Thienemann, Friedrich
Wilkinson, Robert J
Lynen, Lutgarde
Meintjes, Graeme
author_facet Stek, Cari
Shey, Muki
Mnika, Khuthala
Schutz, Charlotte
Thienemann, Friedrich
Wilkinson, Robert J
Lynen, Lutgarde
Meintjes, Graeme
author_sort Stek, Cari
collection PubMed
description The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy.
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spelling pubmed-103754232023-07-29 Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone Stek, Cari Shey, Muki Mnika, Khuthala Schutz, Charlotte Thienemann, Friedrich Wilkinson, Robert J Lynen, Lutgarde Meintjes, Graeme Open Forum Infect Dis Brief Report The development of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and its prevention using prednisone may potentially be mediated by the LTA4H genotype. We assessed this hypothesis in a clinical trial evaluating prednisone to prevent TB-IRIS. We did not find an association between LTA4H genotype and TB-IRIS incidence or prednisone efficacy. Oxford University Press 2023-07-17 /pmc/articles/PMC10375423/ /pubmed/37520416 http://dx.doi.org/10.1093/ofid/ofad379 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Stek, Cari
Shey, Muki
Mnika, Khuthala
Schutz, Charlotte
Thienemann, Friedrich
Wilkinson, Robert J
Lynen, Lutgarde
Meintjes, Graeme
Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone
title Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone
title_full Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone
title_fullStr Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone
title_full_unstemmed Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone
title_short Relationship Between LTA4H Promotor Polymorphism and Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and Its Prevention With Prednisone
title_sort relationship between lta4h promotor polymorphism and tuberculosis-associated immune reconstitution inflammatory syndrome and its prevention with prednisone
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375423/
https://www.ncbi.nlm.nih.gov/pubmed/37520416
http://dx.doi.org/10.1093/ofid/ofad379
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