Discovery of High-Affinity Amyloid Ligands Using a Ligand-Based Virtual Screening Pipeline

[Image: see text] Fibrillar protein aggregates are characteristic of neurodegenerative diseases but represent difficult targets for ligand design, because limited structural information about the binding sites is available. Ligand-based virtual screening has been used to develop a computational meth...

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Detalles Bibliográficos
Autores principales: Chisholm, Timothy S., Mackey, Mark, Hunter, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375536/
https://www.ncbi.nlm.nih.gov/pubmed/37439212
http://dx.doi.org/10.1021/jacs.3c03749

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375536/
https://www.ncbi.nlm.nih.gov/pubmed/37439212
http://dx.doi.org/10.1021/jacs.3c03749

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