Morphological and transcriptomic analyses of stem cell-derived cortical neurons reveal mechanisms underlying synaptic dysfunction in schizophrenia

BACKGROUND: Postmortem studies in schizophrenia consistently show reduced dendritic spines in the cerebral cortex but the mechanistic underpinnings of these deficits remain unknown. Recent genome-wide association studies and exome sequencing investigations implicate synaptic genes and processes in t...

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Detalles Bibliográficos
Autores principales: Kathuria, Annie, Lopez-Lengowski, Kara, Watmuff, Bradley, Karmacharya, Rakesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375745/
https://www.ncbi.nlm.nih.gov/pubmed/37507766
http://dx.doi.org/10.1186/s13073-023-01203-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375745/
https://www.ncbi.nlm.nih.gov/pubmed/37507766
http://dx.doi.org/10.1186/s13073-023-01203-5

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