Synthesis of phthalazine-based derivatives as selective anti-breast cancer agents through EGFR-mediated apoptosis: in vitro and in silico studies

The parent 2-(4-benzyl-1-oxophthalazin-2(1H)-yl)-acetohydrazide (4) has twenty-nine compounds. The starting material for their corresponding mono, dipeptides and reactions with active methylene compounds were produced by chemoselective N-alkylation of 4-Benzyl-2H-phthalazin-1-one (2) with ethyl chlo...

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Detalles Bibliográficos
Autores principales: Emam, Sara M., Rayes, Samir M. El, Ali, Ibrahim A. I., Soliman, Hamdy A., Nafie, Mohamed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375784/
https://www.ncbi.nlm.nih.gov/pubmed/37501139
http://dx.doi.org/10.1186/s13065-023-00995-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375784/
https://www.ncbi.nlm.nih.gov/pubmed/37501139
http://dx.doi.org/10.1186/s13065-023-00995-2

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