Direct Cytosolic Delivery of Proteins and CRISPR-Cas9 Genome Editing by Gemini Amphiphiles via Non-Endocytic Translocation Pathways

[Image: see text] Intracellular delivery of therapeutic biomacromolecules is often challenged by the poor transmembrane and limited endosomal escape. Here, we establish a combinatorial library composed of 150 molecular weight-defined gemini amphiphiles (GAs) to identify the vehicles that facilitate...

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Detalles Bibliográficos
Autores principales: Le, Zhicheng, Pan, Qi, He, Zepeng, Liu, Hong, Shi, Yi, Liu, Lixin, Liu, Zhijia, Ping, Yuan, Chen, Yongming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375873/
https://www.ncbi.nlm.nih.gov/pubmed/37521791
http://dx.doi.org/10.1021/acscentsci.3c00207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375873/
https://www.ncbi.nlm.nih.gov/pubmed/37521791
http://dx.doi.org/10.1021/acscentsci.3c00207

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