Click Chemistry Selectively Activates an Auristatin Protodrug with either Intratumoral or Systemic Tumor-Targeting Agents

[Image: see text] The Click Activated Protodrugs Against Cancer (CAPAC) platform enables the activation of powerful cancer drugs at tumors. CAPAC utilizes a click chemistry reaction between tetrazine and trans-cyclooctene. The reaction between activator, linked to a tumor-targeting agent, and protod...

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Detalles Bibliográficos
Autores principales: McFarland, Jesse M., Alečković, Maša, Coricor, George, Srinivasan, Sangeetha, Tso, Matthew, Lee, John, Nguyen, Tri-Hung, Mejía Oneto, José M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375897/
https://www.ncbi.nlm.nih.gov/pubmed/37521794
http://dx.doi.org/10.1021/acscentsci.3c00365

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375897/
https://www.ncbi.nlm.nih.gov/pubmed/37521794
http://dx.doi.org/10.1021/acscentsci.3c00365

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