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Click Chemistry Selectively Activates an Auristatin Protodrug with either Intratumoral or Systemic Tumor-Targeting Agents

[Image: see text] The Click Activated Protodrugs Against Cancer (CAPAC) platform enables the activation of powerful cancer drugs at tumors. CAPAC utilizes a click chemistry reaction between tetrazine and trans-cyclooctene. The reaction between activator, linked to a tumor-targeting agent, and protod...

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Detalles Bibliográficos
Autores principales:	McFarland, Jesse M., Alečković, Maša, Coricor, George, Srinivasan, Sangeetha, Tso, Matthew, Lee, John, Nguyen, Tri-Hung, Mejía Oneto, José M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10375897/ https://www.ncbi.nlm.nih.gov/pubmed/37521794 http://dx.doi.org/10.1021/acscentsci.3c00365

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