Cargando…

A Novel ENU-Induced Mfn2 Mutation Causes Motor Deficits in Mice without Causing Peripheral Neuropathy

SIMPLE SUMMARY: The fission and fusion of mitochondria are important processes for maintaining mitochondrial health. One of the proteins responsible for mediating mitochondrial fusion, mitofusin 2 (MFN2), has over 100 known mutations that cause Charcot–Marie–Tooth disease type 2A (CMT2A). This disea...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hines, Timothy J., Bailey, Janice, Liu, Hedi, Guntur, Anyonya R., Seburn, Kevin L., Pratt, Samia L., Funke, Jonathan R., Tarantino, Lisa M., Burgess, Robert W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376023/ https://www.ncbi.nlm.nih.gov/pubmed/37508383 http://dx.doi.org/10.3390/biology12070953

Ejemplares similares

Characterization of Highper, an ENU-induced mouse mutant with abnormal psychostimulant and stress responses
por: Eisener-Dorman, Amy F., et al.
Publicado: (2012)

MFN2 mutations cause compensatory mitochondrial DNA proliferation
por: Sitarz, Kamil S., et al.
Publicado: (2012)

Two ENU-Induced Alleles of Atp2b2 Cause Deafness in Mice
por: Carpinelli, Marina R., et al.
Publicado: (2013)

Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death
por: Han, Song, et al.
Publicado: (2020)

Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations
por: Detmer, Scott A., et al.
Publicado: (2007)

Correction: Two ENU-Induced Alleles of Atp2b2 Cause Deafness in Mice
por: Carpinelli, Marina R., et al.
Publicado: (2013)

Clinical and genetic features of a cohort of patients with MFN2-related neuropathy
por: Abati, Elena, et al.
Publicado: (2022)

A Novel ENU-Induced Mutation in Myo6 Causes Vestibular Dysfunction and Deafness
por: Wong, Elaine Y. M., et al.
Publicado: (2016)

A novel ENU-induced Cpox mutation causes microcytic hypochromic anemia in mice
por: Miyasaka, Yuki, et al.
Publicado: (2022)

Functional annotation and ENU
por: Gunn, Teresa M
Publicado: (2012)

Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex
por: Jiang, Sirui, et al.
Publicado: (2018)

MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice
por: Miao, Junru, et al.
Publicado: (2021)

Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2
por: Sloat, S. R., et al.
Publicado: (2019)

Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction
por: Hall, A R, et al.
Publicado: (2016)

A Mutation in Synaptojanin 2 Causes Progressive Hearing Loss in the ENU-Mutagenised Mouse Strain Mozart
por: Manji, Shehnaaz S. M., et al.
Publicado: (2011)

ENU Mutagenesis Identifies Mice with Morbid Obesity and Severe Hyperinsulinemia Caused by a Novel Mutation in Leptin
por: Hong, Chen-Jee, et al.
Publicado: (2010)

The MFN1 and MFN2 mitofusins promote clustering between mitochondria and peroxisomes
por: Huo, Yinbo, et al.
Publicado: (2022)

Correction: Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction
por: Hall, A. R., et al.
Publicado: (2021)

Homozygous mutation in HSPB1 causing distal vacuolar myopathy and motor neuropathy
por: Bugiardini, Enrico, et al.
Publicado: (2017)

An ENU-Induced Mutation of Nrg1 Causes Dilated Pupils and a Reduction in Muscarinic Receptors in the Sphincter Pupillae
por: Chen, Bing, et al.
Publicado: (2011)

Melody, an ENU mutation in Caspase 3, alters the catalytic cysteine residue and causes sensorineural hearing loss in mice
por: Parker, Andrew, et al.
Publicado: (2010)

Novel ENU-Induced Mutation in Tbx6 Causes Dominant Spondylocostal Dysostosis-Like Vertebral Malformations in the Rat
por: Abe, Koichiro, et al.
Publicado: (2015)

Measurement of the pi --> e.nu branching ratio
por: Bryman, D A, et al.
Publicado: (1994)

Search for W --> e.nu decays
por: Givernaud, Alain
Publicado: (1983)

Search for W --> enu in UA2
por: Mapelli, Livio P
Publicado: (1983)

Probability of phenotypically detectable protein damage by ENU-induced mutations in the Mutagenetix database
por: Wang, Tao, et al.
Publicado: (2018)

Gnaq(M1J): An ENU induced mutant allele affecting pigmentation in the mouse
por: Pratt, C. Herbert, et al.
Publicado: (2016)

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
por: Chen, Hsiuchen, et al.
Publicado: (2003)

MFN2 Plays a Distinct Role from MFN1 in Regulating Spermatogonial Differentiation
por: Chen, Wei, et al.
Publicado: (2020)

New insights into behaviour using mouse ENU mutagenesis
por: Oliver, Peter L., et al.
Publicado: (2012)

Correction: Novel ENU-Induced Mutation in Tbx6 Causes Dominant Spondylocostal Dysostosis-Like Vertebral Malformations in the Rat
por: Abe, Koichiro, et al.
Publicado: (2015)

Charcot-Marie-Tooth neuropathy type 2A: novel mutations in the mitofusin 2 gene (MFN2)
por: Engelfried, Kathrin, et al.
Publicado: (2006)

In vivo catecholaminergic metabolism in the medial prefrontal cortex of ENU2 mice: an investigation of the cortical dopamine deficit in phenylketonuria
por: Pascucci, Tiziana, et al.
Publicado: (2012)

Lampe1: An ENU-Germline Mutation Causing Spontaneous Hepatosteatosis Identified through Targeted Exon-Enrichment and Next-Generation Sequencing
por: Sheridan, Rachel, et al.
Publicado: (2011)

Effects of PTH on osteoblast bioenergetics in response to glucose
por: DeMambro, Victoria E., et al.
Publicado: (2023)

Toxic optic neuropathy: An unusual cause
por: Ramkumar, Hema L, et al.
Publicado: (2014)

ENU-induced phenovariance in mice: inferences from 587 mutations
por: Arnold, Carrie N, et al.
Publicado: (2012)

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse
por: Tomberg, Kärt, et al.
Publicado: (2018)

Mitochondrial Dynamics Related Genes -MFN1, MFN2 and DRP1 Polymorphisms are Associated with Risk of Lung Cancer
por: Liang, Xiaohua, et al.
Publicado: (2021)

Mitofusins Mfn1 and Mfn2 Are Required to Preserve Glucose- but Not Incretin-Stimulated β-Cell Connectivity and Insulin Secretion
por: Georgiadou, Eleni, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_5vjcrnuiu8bt9mttfmf4ges5bb