Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity

Although structurally similar to type II counterparts, type I or activin receptor-like kinases (ALKs) are set apart by a metastable helix–loop–helix (HLH) element preceding the protein kinase domain that, according to a longstanding paradigm, serves passive albeit critical roles as an inhibitor-to-s...

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Detalles Bibliográficos
Autores principales: Groppe, Jay C., Lu, Guorong, Tandang-Silvas, Mary R., Pathi, Anupama, Konda, Shruti, Wu, Jingfeng, Le, Viet Q., Culbert, Andria L., Shore, Eileen M., Wharton, Kristi A., Kaplan, Frederick S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376983/
https://www.ncbi.nlm.nih.gov/pubmed/37509165
http://dx.doi.org/10.3390/biom13071129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376983/
https://www.ncbi.nlm.nih.gov/pubmed/37509165
http://dx.doi.org/10.3390/biom13071129

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