An Autophagy-Associated MITF–GAS5–miR-23 Loop Attenuates Vascular Oxidative and Inflammatory Damage in Sepsis

Background: Sepsis induces GAS5 expression in the vascular endothelium, but the molecular mechanism is unclear, as is the role of GAS5 in sepsis. Methods and results: We observed that GAS5 expression in the endothelium was significantly upregulated in a sepsis mouse model. ChIP-PCR and EMSA confirme...

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Detalles Bibliográficos
Autores principales: Cheng, Junning, Ding, Chang, Tang, Huying, Zhou, Haonan, Wu, Mingdong, Chen, Yikuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376991/
https://www.ncbi.nlm.nih.gov/pubmed/37509452
http://dx.doi.org/10.3390/biomedicines11071811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376991/
https://www.ncbi.nlm.nih.gov/pubmed/37509452
http://dx.doi.org/10.3390/biomedicines11071811

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