Novel Iron Chelator SK4 Drives Cytotoxicity through Inhibiting Mitochondrial Metabolism in Ovarian and Triple Negative Breast Cancer Cell Lines

Anti-cancer therapy by iron chelation has been shown to inhibit many cellular processes including DNA replication, mitochondrial metabolism and oncogenic signalling pathways (e.g., EGFR). Iron chelator SK4 represents a double pronged approach towards treating cancer. SK4 enters through LAT1, a commo...

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Detalles Bibliográficos
Autores principales: Abdelaal, Gina, Carter, Andrew, Cheung, William, Panayiotidis, Mihalis, Racey, Seth, Tétard, David, Veuger, Stephany
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377004/
https://www.ncbi.nlm.nih.gov/pubmed/37509712
http://dx.doi.org/10.3390/biomedicines11072073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377004/
https://www.ncbi.nlm.nih.gov/pubmed/37509712
http://dx.doi.org/10.3390/biomedicines11072073

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