Cargando…
What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease?
Background and Objective: Dietary constituents may affect the progression of Parkinson’s disease (PD). This study aimed to assess the contribution of dietary intake of vitamins and minerals to the severity, motor and non-motor symptoms, and risk of PD. Methods: In this case-control study, 120 patien...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377174/ https://www.ncbi.nlm.nih.gov/pubmed/37509049 http://dx.doi.org/10.3390/brainsci13071119 |
_version_ | 1785079452299952128 |
---|---|
author | Alizadeh, Mohammad Kheirouri, Sorayya Keramati, Majid |
author_facet | Alizadeh, Mohammad Kheirouri, Sorayya Keramati, Majid |
author_sort | Alizadeh, Mohammad |
collection | PubMed |
description | Background and Objective: Dietary constituents may affect the progression of Parkinson’s disease (PD). This study aimed to assess the contribution of dietary intake of vitamins and minerals to the severity, motor and non-motor symptoms, and risk of PD. Methods: In this case-control study, 120 patients with PD and 50 healthy participants participated. Dietary intake of vitamins and minerals was determined using a 147-item food frequency questionnaire. The severity of PD was determined by the Unified Parkinson’s Disease Rating Scale (UPDRS). Results: Patients with PD had lower intake of several vitamins and minerals including lycopene, thiamine, vitamin B6, vitamin B12, pantothenic acid, magnesium, zinc, manganese, selenium, chromium, and phosphorus, but had higher intake of α-tocopherol. High dietary intake of vitamin A, α-carotene, β-cryptoxanthin, vitamin C, and α-tocopherol were correlated with increased odds of PD. High intake of lycopene, thiamin, vitamin B6, pantothenic acid, magnesium, zinc, manganese, chromium, and phosphorous correlated with reduced odds of PD. The predictive power of α-tocopherol concerning the risk of PD was stronger relative to other vitamins. Dietary intake of pantothenic acid was negatively correlated with PD severity and symptoms of motor examination and complication. The severity and motor symptoms of PD were also negatively correlated with β-carotene, vitamin C, riboflavin, vitamin B6, and biotin intake. The UPDRS total score and motor symptoms in PD patients were negatively correlated with phosphorus, magnesium, zinc, manganese, and chromium, and strongly with potassium intake. Conclusion: The findings indicate that adequate dietary intake of vitamins and minerals may have a preventive effect on developing PD and progression of motor decline. |
format | Online Article Text |
id | pubmed-10377174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103771742023-07-29 What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease? Alizadeh, Mohammad Kheirouri, Sorayya Keramati, Majid Brain Sci Article Background and Objective: Dietary constituents may affect the progression of Parkinson’s disease (PD). This study aimed to assess the contribution of dietary intake of vitamins and minerals to the severity, motor and non-motor symptoms, and risk of PD. Methods: In this case-control study, 120 patients with PD and 50 healthy participants participated. Dietary intake of vitamins and minerals was determined using a 147-item food frequency questionnaire. The severity of PD was determined by the Unified Parkinson’s Disease Rating Scale (UPDRS). Results: Patients with PD had lower intake of several vitamins and minerals including lycopene, thiamine, vitamin B6, vitamin B12, pantothenic acid, magnesium, zinc, manganese, selenium, chromium, and phosphorus, but had higher intake of α-tocopherol. High dietary intake of vitamin A, α-carotene, β-cryptoxanthin, vitamin C, and α-tocopherol were correlated with increased odds of PD. High intake of lycopene, thiamin, vitamin B6, pantothenic acid, magnesium, zinc, manganese, chromium, and phosphorous correlated with reduced odds of PD. The predictive power of α-tocopherol concerning the risk of PD was stronger relative to other vitamins. Dietary intake of pantothenic acid was negatively correlated with PD severity and symptoms of motor examination and complication. The severity and motor symptoms of PD were also negatively correlated with β-carotene, vitamin C, riboflavin, vitamin B6, and biotin intake. The UPDRS total score and motor symptoms in PD patients were negatively correlated with phosphorus, magnesium, zinc, manganese, and chromium, and strongly with potassium intake. Conclusion: The findings indicate that adequate dietary intake of vitamins and minerals may have a preventive effect on developing PD and progression of motor decline. MDPI 2023-07-24 /pmc/articles/PMC10377174/ /pubmed/37509049 http://dx.doi.org/10.3390/brainsci13071119 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alizadeh, Mohammad Kheirouri, Sorayya Keramati, Majid What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease? |
title | What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease? |
title_full | What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease? |
title_fullStr | What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease? |
title_full_unstemmed | What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease? |
title_short | What Dietary Vitamins and Minerals Might Be Protective against Parkinson’s Disease? |
title_sort | what dietary vitamins and minerals might be protective against parkinson’s disease? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377174/ https://www.ncbi.nlm.nih.gov/pubmed/37509049 http://dx.doi.org/10.3390/brainsci13071119 |
work_keys_str_mv | AT alizadehmohammad whatdietaryvitaminsandmineralsmightbeprotectiveagainstparkinsonsdisease AT kheirourisorayya whatdietaryvitaminsandmineralsmightbeprotectiveagainstparkinsonsdisease AT keramatimajid whatdietaryvitaminsandmineralsmightbeprotectiveagainstparkinsonsdisease |