A2AR Expression and Immunosuppressive Environment Independent of KRAS and GNAS Mutations in Pseudomyxoma Peritonei

In pseudomyxoma peritonei (PMP), KRAS and GNAS mutations are frequent. We hypothesized that these mutations may contribute to the suppression of antitumor immunity: KRAS may induce GMCSF expression, while GNAS may enhance the expression of cyclic adenosine monophosphate and A2AR signaling. This stud...

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Detalles Bibliográficos
Autores principales: Kusamura, Shigeki, Busico, Adele, Conca, Elena, Capone, Iolanda, Agnelli, Luca, Lorenzini, Daniele, Brich, Silvia, Angelini, Marta, Volpi, Chiara Costanza, Trupia, Desirè Viola, Lagano, Vincenzo, Torelli, Tommaso, Gloghini, Annunziata, Baratti, Dario, Guaglio, Marcello, Milione, Massimo, Deraco, Marcello, Perrone, Federica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377259/
https://www.ncbi.nlm.nih.gov/pubmed/37509688
http://dx.doi.org/10.3390/biomedicines11072049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377259/
https://www.ncbi.nlm.nih.gov/pubmed/37509688
http://dx.doi.org/10.3390/biomedicines11072049

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