Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D(3) and Identification of Their Metabolites

Vitamin D(3) (1) is metabolized by various cytochrome P450 (CYP) enzymes, resulting in the formation of diverse metabolites. Among them, 4α,25-dihydroxyvitamin D(3) (6a) and 4β,25-dihydroxyvitamin D(3) (6b) are both produced from 25-hydroxyvitamin D(3) (2) by CYP3A4. However, 6b is detectable in ser...

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Detalles Bibliográficos
Autores principales: Mizumoto, Yuka, Sakamoto, Ryota, Iijima, Kazuto, Nakaya, Naoto, Odagi, Minami, Tera, Masayuki, Hirokawa, Takatsugu, Sakaki, Toshiyuki, Yasuda, Kaori, Nagasawa, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377336/
https://www.ncbi.nlm.nih.gov/pubmed/37509072
http://dx.doi.org/10.3390/biom13071036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377336/
https://www.ncbi.nlm.nih.gov/pubmed/37509072
http://dx.doi.org/10.3390/biom13071036

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