The Development of p53-Targeted Therapies for Human Cancers

SIMPLE SUMMARY: Dysfunction of p53 has a significant impact on the resistance of tumor cells to various therapeutic agents. The major mechanisms causing p53 dysfunction include the MDM2/MDMX-mediated destabilization and inactivation of wtp53 and somatic p53 mutations. Despite an intensive search for...

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Detalles Bibliográficos
Autores principales: Lu, Yier, Wu, Meng, Xu, Yang, Yu, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377496/
https://www.ncbi.nlm.nih.gov/pubmed/37509223
http://dx.doi.org/10.3390/cancers15143560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377496/
https://www.ncbi.nlm.nih.gov/pubmed/37509223
http://dx.doi.org/10.3390/cancers15143560

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