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The Development of p53-Targeted Therapies for Human Cancers
SIMPLE SUMMARY: Dysfunction of p53 has a significant impact on the resistance of tumor cells to various therapeutic agents. The major mechanisms causing p53 dysfunction include the MDM2/MDMX-mediated destabilization and inactivation of wtp53 and somatic p53 mutations. Despite an intensive search for...
Autores principales: | Lu, Yier, Wu, Meng, Xu, Yang, Yu, Lili |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377496/ https://www.ncbi.nlm.nih.gov/pubmed/37509223 http://dx.doi.org/10.3390/cancers15143560 |
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