Generation of Orthotopic Patient-Derived Xenografts in Humanized Mice for Evaluation of Emerging Targeted Therapies and Immunotherapy Combinations for Melanoma

SIMPLE SUMMARY: Patient-derived xenografts (PDX) are valuable models in preclinical oncology drug development. However, they are not well suited for testing immune-based therapies. In contrast, when humanized mice are developed by xenotransplantation of irradiated mice with human CD34+ stem cells to...

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Detalles Bibliográficos
Autores principales: Yan, Chi, Nebhan, Caroline A., Saleh, Nabil, Shattuck-Brandt, Rebecca, Chen, Sheau-Chiann, Ayers, Gregory D., Weiss, Vivian, Richmond, Ann, Vilgelm, Anna E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377652/
https://www.ncbi.nlm.nih.gov/pubmed/37509357
http://dx.doi.org/10.3390/cancers15143695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377652/
https://www.ncbi.nlm.nih.gov/pubmed/37509357
http://dx.doi.org/10.3390/cancers15143695

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