Cargando…

Generation of Orthotopic Patient-Derived Xenografts in Humanized Mice for Evaluation of Emerging Targeted Therapies and Immunotherapy Combinations for Melanoma

SIMPLE SUMMARY: Patient-derived xenografts (PDX) are valuable models in preclinical oncology drug development. However, they are not well suited for testing immune-based therapies. In contrast, when humanized mice are developed by xenotransplantation of irradiated mice with human CD34+ stem cells to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yan, Chi, Nebhan, Caroline A., Saleh, Nabil, Shattuck-Brandt, Rebecca, Chen, Sheau-Chiann, Ayers, Gregory D., Weiss, Vivian, Richmond, Ann, Vilgelm, Anna E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377652/ https://www.ncbi.nlm.nih.gov/pubmed/37509357 http://dx.doi.org/10.3390/cancers15143695

Ejemplares similares

Novel induction of CD40 expression by tumor cells with RAS/RAF/PI3K pathway inhibition augments response to checkpoint blockade
por: Yan, Chi, et al.
Publicado: (2021)

Proximity of immune and tumor cells underlies response to BRAF/MEK-targeted therapies in metastatic melanoma patients
por: Yan, Chi, et al.
Publicado: (2022)

Inhibition of the PI3K/mTOR Pathway in Breast Cancer to Enhance Response to Immune Checkpoint Inhibitors in Breast Cancer
por: Yan, Chi, et al.
Publicado: (2021)

Chemokines Modulate Immune Surveillance in Tumorigenesis, Metastasis, and Response to Immunotherapy
por: Vilgelm, Anna E., et al.
Publicado: (2019)

MDM2 Antagonists Counteract Drug-Induced DNA Damage
por: Vilgelm, Anna E., et al.
Publicado: (2017)

Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma †
por: Hoffman, Robert M.
Publicado: (2017)

The Yin/Yan of CCL2: a minor role in neutrophil anti-tumor activity in vitro but a major role on the outgrowth of metastatic breast cancer lesions in the lung in vivo
por: Lavender, Nicole, et al.
Publicado: (2017)

Orthotopic xenografts of human melanoma and colonic and ovarian carcinoma in sheep to evaluate radioimmunotherapy.
por: Turner, J. H., et al.
Publicado: (1998)

Development and optimization of orthotopic liver metastasis xenograft mouse models in uveal melanoma
por: Sugase, Takahito, et al.
Publicado: (2020)

Establishment of an orthotopic patient-derived xenograft mouse model using uveal melanoma hepatic metastasis
por: Kageyama, Ken, et al.
Publicado: (2017)

Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor
por: Sicklick, Jason K, et al.
Publicado: (2014)

Minimally Invasive Establishment of Murine Orthotopic Bladder Xenografts
por: Jäger, Wolfgang, et al.
Publicado: (2014)

Development and characterization of a human orthotopic neuroblastoma xenograft
por: Stewart, Elizabeth, et al.
Publicado: (2015)

Orthotopic Patient-Derived Xenografts of Pediatric Solid Tumors
por: Stewart, Elizabeth, et al.
Publicado: (2017)

Orthotopic tumours, a hot topic for xenograft models?
por: Zheng, Dali
Publicado: (2019)

Dasatinib enhances tumor growth in gemcitabine-resistant orthotopic bladder cancer xenografts
por: Vallo, Stefan, et al.
Publicado: (2016)

Orthotopic human melanoma xenograft model systems for studies of tumour angiogenesis, pathophysiology, treatment sensitivity and metastatic pattern.
por: Rofstad, E. K.
Publicado: (1994)

Photosubstitution in a trisheteroleptic ruthenium complex inhibits conjunctival melanoma growth in a zebrafish orthotopic xenograft model
por: Chen, Quanchi, et al.
Publicado: (2022)

Illuminating the mechanism of IL-6-mediated immunotherapy resistance
por: Vilgelm, Anna E.
Publicado: (2023)

Survival following complete resection of neuroblastoma in novel orthotopic rat xenograft model
por: Sever, ReidAnn E., et al.
Publicado: (2023)

Generation of glioblastoma patient-derived organoids and mouse brain orthotopic xenografts for drug screening
por: Gamboa, Christian Moya, et al.
Publicado: (2021)

Generation of orthotopic patient-derived xenograft models for pancreatic cancer using tumor slices
por: Curiel-Garcia, Alvaro, et al.
Publicado: (2022)

An orthotopic xenograft model of human nonseminomatous germ cell tumour
por: Douglas, M L, et al.
Publicado: (2001)

Dynamic Quantitative T1 Mapping in Orthotopic Brain Tumor Xenografts()
por: Herrmann, Kelsey, et al.
Publicado: (2016)

TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis
por: Gore, Jesse, et al.
Publicado: (2015)

Multimodality Imaging Methods for Assessing Retinoblastoma Orthotopic Xenograft Growth and Development
por: Corson, Timothy W., et al.
Publicado: (2014)

Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts
por: Koessinger, Anna L., et al.
Publicado: (2020)

Eribulin prolongs survival in an orthotopic xenograft mouse model of malignant meningioma
por: Nakano, Tomoyuki, et al.
Publicado: (2021)

Clinically relevant orthotopic xenograft models of patient-derived glioblastoma in zebrafish
por: Ai, Xiaolin, et al.
Publicado: (2022)

Establishment of an orthotopic perirenal space xenograft mouse model of retroperitoneal sarcoma
por: Xie, Fu'an, et al.
Publicado: (2021)

Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors
por: Oudin, Anaïs, et al.
Publicado: (2021)

Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model
por: Yamamoto, Mako, et al.
Publicado: (2016)

The effect of chemotherapeutic agents on tumor vasculature in subcutaneous and orthotopic human tumor xenografts
por: Fung, Andrea S, et al.
Publicado: (2015)

Hedgehog inhibition enhances efficacy of radiation and cisplatin in orthotopic cervical cancer xenografts
por: Chaudary, Naz, et al.
Publicado: (2017)

Utility of Glioblastoma Patient-Derived Orthotopic Xenografts in Drug Discovery and Personalized Therapy
por: Patrizii, Michele, et al.
Publicado: (2018)

Identification and causes of metabonomic difference between orthotopic and subcutaneous xenograft of pancreatic cancer
por: Zhan, Bohan, et al.
Publicado: (2017)

Human mesenchymal stromal cells inhibit tumor growth in orthotopic glioblastoma xenografts
por: Pacioni, Simone, et al.
Publicado: (2017)

Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Primary and Recurrent Meningioma
por: Zhang, Huiyuan, et al.
Publicado: (2020)

Ultrasound-Guided Approaches to Improve Orthotopic Mouse Xenograft Models for Hepatocellular Carcinoma
por: About, Ghina Bou, et al.
Publicado: (2019)

Neuroblastoma patient-derived orthotopic xenografts retain metastatic patterns and geno- and phenotypes of patient tumours
por: Braekeveldt, Noémie, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_qd7ijd62lh802lasdtkie579n7