Individual Contributions of Amido Acid Residues Tyr122, Ile168, and Asp173 to the Activity and Substrate Specificity of Human DNA Dioxygenase ABH2

Human Fe(II)/α-ketoglutarate-dependent dioxygenase ABH2 plays a crucial role in the direct reversal repair of nonbulky alkyl lesions in DNA nucleobases, e.g., N(1)-methyladenine (m(1)A), N(3)-methylcytosine (m(3)C), and some etheno derivatives. Moreover, ABH2 is capable of a less efficient oxidation...

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Detalles Bibliográficos
Autores principales: Davletgildeeva, Anastasiia T., Tyugashev, Timofey E., Zhao, Mingxing, Kuznetsov, Nikita A., Ishchenko, Alexander A., Saparbaev, Murat, Kuznetsova, Aleksandra A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377887/
https://www.ncbi.nlm.nih.gov/pubmed/37508504
http://dx.doi.org/10.3390/cells12141839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377887/
https://www.ncbi.nlm.nih.gov/pubmed/37508504
http://dx.doi.org/10.3390/cells12141839

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