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Individual Contributions of Amido Acid Residues Tyr122, Ile168, and Asp173 to the Activity and Substrate Specificity of Human DNA Dioxygenase ABH2
Human Fe(II)/α-ketoglutarate-dependent dioxygenase ABH2 plays a crucial role in the direct reversal repair of nonbulky alkyl lesions in DNA nucleobases, e.g., N(1)-methyladenine (m(1)A), N(3)-methylcytosine (m(3)C), and some etheno derivatives. Moreover, ABH2 is capable of a less efficient oxidation...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377887/ https://www.ncbi.nlm.nih.gov/pubmed/37508504 http://dx.doi.org/10.3390/cells12141839 |