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Ca(2+)-Driven Selectivity of the Effect of the Cardiotonic Steroid Marinobufagenin on Rabbit Sinoatrial Node Function

The synergy between Na(+)-K(+) pumps, Na(+)-Ca(2+) exchangers, membrane currents and the sarcoplasmic reticulum (SR) generates the coupled-clock system, which governs the spontaneous electrical activity of heart sinoatrial node cells (SANCs). Ca(2+) mediates the degree of clock coupling via local Ca...

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Detalles Bibliográficos
Autores principales: Segal, Sofia, Yaniv, Yael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378090/
https://www.ncbi.nlm.nih.gov/pubmed/37508546
http://dx.doi.org/10.3390/cells12141881