Revisiting Two Decades of Research Focused on Targeting APE1 for Cancer Therapy: The Pros and Cons

APE1 is an essential endodeoxyribonuclease of the base excision repair pathway that maintains genome stability. It was identified as a pivotal factor favoring tumor progression and chemoresistance through the control of gene expression by a redox-based mechanism. APE1 is overexpressed and serum-secr...

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Detalles Bibliográficos
Autores principales: Malfatti, Matilde Clarissa, Bellina, Alessia, Antoniali, Giulia, Tell, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378182/
https://www.ncbi.nlm.nih.gov/pubmed/37508559
http://dx.doi.org/10.3390/cells12141895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378182/
https://www.ncbi.nlm.nih.gov/pubmed/37508559
http://dx.doi.org/10.3390/cells12141895

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