S1P Lyase Deficiency in the Brain Promotes Astrogliosis and NLRP3 Inflammasome Activation via Purinergic Signaling

Astrocytes are critical players in brain health and disease. Brain pathologies and lesions are usually accompanied by astroglial alterations known as reactive astrogliosis. Sphingosine 1-phosphate lyase (SGPL1) catalysis, the final step in sphingolipid catabolism, irreversibly cleaves its substrate...

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Detalles Bibliográficos
Autores principales: Alam, Shah, Afsar, Sumaiya Yasmeen, Wolter, Maya Anik, Volk, Luisa Michelle, Mitroi, Daniel Nicolae, Meyer zu Heringdorf, Dagmar, van Echten-Deckert, Gerhild
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378183/
https://www.ncbi.nlm.nih.gov/pubmed/37508508
http://dx.doi.org/10.3390/cells12141844

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378183/
https://www.ncbi.nlm.nih.gov/pubmed/37508508
http://dx.doi.org/10.3390/cells12141844

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