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N-Acetylaspartate Drives Oligodendroglial Differentiation via Histone Deacetylase Activation

An unmet clinical goal in demyelinating pathologies is to restore the myelin sheath prior to neural degeneration. N-acetylaspartate (NAA) is an acetylated derivative form of aspartate, abundant in the healthy brain but severely reduced during traumatic brain injury and in patients with neurodegenera...

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Detalles Bibliográficos
Autores principales: Dominicis, Alessandra, Del Giovane, Alice, Torreggiani, Matteo, Recchia, Antonella Damiana, Ciccarone, Fabio, Ciriolo, Maria Rosa, Ragnini-Wilson, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378218/
https://www.ncbi.nlm.nih.gov/pubmed/37508525
http://dx.doi.org/10.3390/cells12141861