Cargando…

N-Acetylaspartate Drives Oligodendroglial Differentiation via Histone Deacetylase Activation

An unmet clinical goal in demyelinating pathologies is to restore the myelin sheath prior to neural degeneration. N-acetylaspartate (NAA) is an acetylated derivative form of aspartate, abundant in the healthy brain but severely reduced during traumatic brain injury and in patients with neurodegenera...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dominicis, Alessandra, Del Giovane, Alice, Torreggiani, Matteo, Recchia, Antonella Damiana, Ciccarone, Fabio, Ciriolo, Maria Rosa, Ragnini-Wilson, Antonella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378218/ https://www.ncbi.nlm.nih.gov/pubmed/37508525 http://dx.doi.org/10.3390/cells12141861

Ejemplares similares

Smoothened/AMP-Activated Protein Kinase Signaling in Oligodendroglial Cell Maturation
por: Del Giovane, Alice, et al.
Publicado: (2022)

Targeting Smoothened as a New Frontier in the Functional Recovery of Central Nervous System Demyelinating Pathologies
por: Del Giovane, Alice, et al.
Publicado: (2018)

The Current Challenges for Drug Discovery in CNS Remyelination
por: Balestri, Sonia, et al.
Publicado: (2021)

N-Acetylaspartate Metabolism Outside the Brain: Lipogenesis, Histone Acetylation, and Cancer
por: Bogner-Strauss, Juliane G.
Publicado: (2017)

Plasma N-Acetylaspartate Is Related to Age, Obesity, and Glucose Metabolism: Effects of Antidiabetic Treatment and Bariatric Surgery
por: Daniele, Giuseppe, et al.
Publicado: (2020)

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma
por: Phimmachanh, Monica, et al.
Publicado: (2020)

Histone Acetylation and Methylation Underlie Oligodendroglial and Myelin Susceptibility in Schizophrenia
por: Li, Mei, et al.
Publicado: (2022)

N-Acetylaspartate Is an Important Brain Osmolyte
por: Warepam, Marina, et al.
Publicado: (2020)

N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes
por: Prokesch, A., et al.
Publicado: (2016)

Histone‐deacetylase 8 drives the immune response and the growth of glioma
por: Mormino, Alessandro, et al.
Publicado: (2021)

Conserved Molecular Mechanisms Underlying Homeostasis of the Golgi Complex
por: Wilson, Cathal, et al.
Publicado: (2010)

Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates
por: Yao, Ya-Li, et al.
Publicado: (2011)

Protein Kinase C Activation Drives a Differentiation Program in an Oligodendroglial Precursor Model through the Modulation of Specific Biological Networks
por: Damato, Marina, et al.
Publicado: (2021)

Studies on the Role of N-Acetylaspartic Acid in Mammalian Brain
por: Jacobson, K. Bruce
Publicado: (1959)

Extracellular N-Acetylaspartate in Human Traumatic Brain Injury
por: Shannon, Richard J., et al.
Publicado: (2016)

Histone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers
por: Sanaei, Masumeh, et al.
Publicado: (2019)

Oxidative Stress-Driven Autophagy acROSs Onset and Therapeutic Outcome in Hepatocellular Carcinoma
por: Ciccarone, Fabio, et al.
Publicado: (2019)

Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy
por: Desideri, Enrico, et al.
Publicado: (2019)

Adipose Tissue and FoxO1: Bridging Physiology and Mechanisms
por: Ioannilli, Laura, et al.
Publicado: (2020)

Education mitigates age-related decline in N-Acetylaspartate levels
por: Erickson, Kirk I, et al.
Publicado: (2015)

N‐acetylaspartate release by glutaminolytic ovarian cancer cells sustains protumoral macrophages
por: Menga, Alessio, et al.
Publicado: (2021)

Chemical Phylogenetics of Histone Deacetylases
por: Bradner, James E., et al.
Publicado: (2010)

Histone deacetylases in viral infections
por: Herbein, Georges, et al.
Publicado: (2010)

Butyrate Histone Deacetylase Inhibitors
por: Steliou, Kosta, et al.
Publicado: (2012)

Histone deacetylase signaling in cardioprotection
por: Lehmann, Lorenz H., et al.
Publicado: (2013)

Histone deacetylase 6 in cancer
por: Li, Ting, et al.
Publicado: (2018)

EGFR/ErbB Inhibition Promotes OPC Maturation up to Axon Engagement by Co-Regulating PIP2 and MBP
por: Nocita, Emanuela, et al.
Publicado: (2019)

Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8
por: Yan, Wensheng, et al.
Publicado: (2012)

Histone deacetylase 9 regulates breast cancer cell proliferation and the response to histone deacetylase inhibitors
por: Lapierre, Marion, et al.
Publicado: (2016)

Histone Deacetylase Inhibitors Impair Vasculogenic Mimicry from Glioblastoma Cells
por: Pastorino, Olga, et al.
Publicado: (2019)

A yeast-based genomic strategy highlights the cell protein networks altered by FTase inhibitor peptidomimetics
por: Porcu, Giampiero, et al.
Publicado: (2010)

Genetic markers in oligodendroglial tumours
por: Velnar, Tomaz, et al.
Publicado: (2010)

Gene Expression in Oligodendroglial Tumors
por: Shaw, Elisabeth J., et al.
Publicado: (2010)

Oligodendroglial pathology in canine distemper
por: Zurbriggen, A., et al.
Publicado: (1997)

Oligodendroglial Heterogeneity in Neuropsychiatric Disease
por: Bøstrand, Sunniva M. K., et al.
Publicado: (2021)

Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus
por: Huang, Ying, et al.
Publicado: (2011)

Histone deacetylase enzymes and selective histone deacetylase inhibitors for antitumor effects and enhancement of antitumor immunity in glioblastoma
por: Yelton, Caleb J., et al.
Publicado: (2018)

Beyond vascularization: aerobic fitness is associated with N-acetylaspartate and working memory
por: Erickson, Kirk I, et al.
Publicado: (2012)

Brain Metabolite, N-Acetylaspartate Is a Potent Protein Aggregation Inhibitor
por: Warepam, Marina, et al.
Publicado: (2021)

N-Acetylaspartate Biomarker of Stroke Recovery: A Case Series Study
por: Austin, Tyler, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_l4taoq5leh103qdoq803uibs03