Cargando…

The Molecular Pathogenesis of Tumor-Suppressive miR-486-5p and miR-486-3p Target Genes: GINS4 Facilitates Aggressiveness in Lung Adenocarcinoma

SIMPLE SUMMARY: Two microRNAs (miRNAs) (miR-486-5p and miR-486-3p) derived from pre-miR-486 acted as tumor-suppressive miRNAs in lung adenocarcinoma (LUAD). We identified seven genes (MKI67, GINS4, RRM2, HELLS, MELK, TIMELESS, and SAPCD2) involved in the malignant phenotype of LUAD cells coordinatel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tomioka, Yuya, Suetsugu, Takayuki, Seki, Naohiko, Tanigawa, Kengo, Hagihara, Yoko, Shinmura, Masahiro, Asai, Shunichi, Kikkawa, Naoko, Inoue, Hiromasa, Mizuno, Keiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378275/ https://www.ncbi.nlm.nih.gov/pubmed/37508549 http://dx.doi.org/10.3390/cells12141885

Ejemplares similares

FAM64A: A Novel Oncogenic Target of Lung Adenocarcinoma Regulated by Both Strands of miR-99a (miR-99a-5p and miR-99a-3p)
por: Mizuno, Keiko, et al.
Publicado: (2020)

Involvement of Dual Strands of miR-143 (miR-143-5p and miR-143-3p) and Their Target Oncogenes in the Molecular Pathogenesis of Lung Adenocarcinoma
por: Sanada, Hiroki, et al.
Publicado: (2019)

MicroRNA signature of small‐cell lung cancer after treatment failure: impact on oncogenic targets by miR‐30a‐3p control
por: Tanigawa, Kengo, et al.
Publicado: (2022)

Regulation of Oncogenic Targets by Tumor-Suppressive miR-150-3p in Lung Squamous Cell Carcinoma
por: Mizuno, Keiko, et al.
Publicado: (2021)

miR-486-5p expression is regulated by DNA methylation in osteosarcoma
por: Namløs, Heidi M., et al.
Publicado: (2022)

Down-regulation of miR-486-5p expression inhibits the proliferation and invasion of human extravillous trophoblasts, and decreased peripheral plasma miR-486-5p level is associated with human early pregnancy loss: Role of miR-486-5p in human early pregnancy loss
por: Gu, Yan, et al.
Publicado: (2023)

miR-486-3p, miR-139-5p, and miR-21 as Biomarkers for the Detection of Oral Tongue Squamous Cell Carcinoma
por: Chen, Zujian, et al.
Publicado: (2017)

miR-486-3p, miR-139-5p, and miR-21 as Biomarkers for the Detection of Oral Tongue Squamous Cell Carcinoma
por: Chen, Zujian, et al.
Publicado: (2017)

Expression of circulating miR-486 and miR-150 in patients with acute myocardial infarction
por: Zhang, Rui, et al.
Publicado: (2015)

miR-486 is modulated by stretch and increases ventricular growth
por: Lange, Stephan, et al.
Publicado: (2019)

Molecular Pathogenesis of Gene Regulation by the miR-150 Duplex: miR-150-3p Regulates TNS4 in Lung Adenocarcinoma
por: Misono, Shunsuke, et al.
Publicado: (2019)

Expression and Prognostic Value of miR-486-5p in Patients with Gastric Adenocarcinoma
por: Chen, Hui, et al.
Publicado: (2015)

miR-486-5p: A Prognostic Biomarker for Chronic Myeloid Leukemia
por: Ninawe, Anupama, et al.
Publicado: (2021)

Evaluation of the Expression of miR-486-3p, miR-548-3p, miR-561-5p and miR-509-5p in Tumor Biopsies of Patients with Oral Squamous Cell Carcinoma
por: Garajei, Ata, et al.
Publicado: (2022)

MiR-486-5p negatively regulates oncogenic NEK2 in hepatocellular carcinoma
por: Fu, Shun-Jun, et al.
Publicado: (2017)

Downregulation of KIAA1199 by miR‐486‐5p suppresses tumorigenesis in lung cancer
por: Wang, Anqi, et al.
Publicado: (2020)

miR-486-5p and miR-22-3p Enable Megakaryocytic Differentiation of Hematopoietic Stem and Progenitor Cells without Thrombopoietin
por: Kao, Chen-Yuan, et al.
Publicado: (2022)

miR-196b, miR-378a and miR-486 are predictive biomarkers for the efficacy of vaccine treatment in colorectal cancer
por: Shindo, Yoshitaro, et al.
Publicado: (2017)

PAX3-FOXO1 drives miR-486-5p and represses miR-221 contributing to pathogenesis of alveolar rhabdomyosarcoma
por: Hanna, Jason A., et al.
Publicado: (2018)

MicroRNA profiling reveals that miR-21, miR486 and miR-214 are upregulated and involved in cell survival in Sézary syndrome
por: Narducci, M G, et al.
Publicado: (2011)

Regulation of Oncogenic Targets by the Tumor-Suppressive miR-139 Duplex (miR-139-5p and miR-139-3p) in Renal Cell Carcinoma
por: Okada, Reona, et al.
Publicado: (2020)

miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway
por: He, Ming, et al.
Publicado: (2017)

miR-486 is essential for muscle function and suppresses a dystrophic transcriptome
por: Samani, Adrienne, et al.
Publicado: (2022)

miR-486 suppresses the development of osteosarcoma by regulating PKC-δ pathway
por: He, Ming, et al.
Publicado: (2023)

Elevated IgE promotes cardiac fibrosis by suppressing miR-486a-5p
por: Zhao, Hongmei, et al.
Publicado: (2021)

Oral Spirochete Treponema denticola Intraoral Infection Reveals Unique miR-133a, miR-486, miR-126-3p, miR-126-5p miRNA Expression Kinetics during Periodontitis
por: Aravindraja, Chairmandurai, et al.
Publicado: (2023)

Identification of Tumor Suppressive Genes Regulated by miR-31-5p and miR-31-3p in Head and Neck Squamous Cell Carcinoma
por: Oshima, Sachi, et al.
Publicado: (2021)

Serum miR-486-5p as a diagnostic marker in cervical cancer: with investigation of potential mechanisms
por: Li, Chunmei, et al.
Publicado: (2018)

miR-486-5p attenuates tumor growth and lymphangiogenesis by targeting neuropilin-2 in colorectal carcinoma
por: Liu, Chengxia, et al.
Publicado: (2016)

Estrogen receptor-mediated miR-486-5p regulation of OLFM4 expression in ovarian cancer
por: Ma, Hanyu, et al.
Publicado: (2016)

MiR-486-3p inhibits the proliferation, migration and invasion of retinoblastoma cells by targeting ECM1
por: Yang, Hongwei, et al.
Publicado: (2020)

miR-486-3p mediates hepatocellular carcinoma sorafenib resistance by targeting FGFR4 and EGFR
por: Ji, Lin, et al.
Publicado: (2020)

Diagnostic and prognostic value of miR-486-5p, miR-451a, miR-21-5p and monocyte to high-density lipoprotein cholesterol ratio in patients with acute myocardial infarction
por: Xu, Liwenjing, et al.
Publicado: (2022)

MiR-486 Regulates Lactation and Targets the PTEN Gene in Cow Mammary Glands
por: Li, Dan, et al.
Publicado: (2015)

Minichromosome maintenance proteins in lung adenocarcinoma: Clinical significance and therapeutic targets
por: Tanigawa, Kengo, et al.
Publicado: (2023)

Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma
por: Koma, Ayaka, et al.
Publicado: (2021)

circ-BPTF serves as a miR-486-5p sponge to regulate CEMIP and promotes hypoxic pulmonary arterial smooth muscle cell proliferation in COPD: Hpoxia induces circ-BPTF/miR-486-5p/CEMIP axis in COPD
por: Wang, Changguo, et al.
Publicado: (2022)

Identification of miR-199-5p and miR-199-3p Target Genes: Paxillin Facilities Cancer Cell Aggressiveness in Head and Neck Squamous Cell Carcinoma
por: Tanaka, Nozomi, et al.
Publicado: (2021)

miR-486-5p suppresses prostate cancer metastasis by targeting Snail and regulating epithelial–mesenchymal transition
por: Zhang, Xiaoguang, et al.
Publicado: (2016)

MiR-486 regulates cardiomyocyte apoptosis by p53-mediated BCL-2 associated mitochondrial apoptotic pathway
por: Sun, Yuhan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bmagfs3offb342qgq6s7igdfml