Unveiling the Therapeutic Potential of Squalene Synthase: Deciphering Its Biochemical Mechanism, Disease Implications, and Intriguing Ties to Ferroptosis

SIMPLE SUMMARY: Squalene synthase is a key enzyme that not only participates in the mevalonate pathway, resulting in cholesterol, but also acts as a potential ferroptosis regulator. The synthesis of squalene and its release in the endoplasmic reticulum protects the cell against lipid peroxidation, r...

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Detalles Bibliográficos
Autores principales: Picón, David Figueredo, Skouta, Rachid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378455/
https://www.ncbi.nlm.nih.gov/pubmed/37509391
http://dx.doi.org/10.3390/cancers15143731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378455/
https://www.ncbi.nlm.nih.gov/pubmed/37509391
http://dx.doi.org/10.3390/cancers15143731

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