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Unveiling the Therapeutic Potential of Squalene Synthase: Deciphering Its Biochemical Mechanism, Disease Implications, and Intriguing Ties to Ferroptosis
SIMPLE SUMMARY: Squalene synthase is a key enzyme that not only participates in the mevalonate pathway, resulting in cholesterol, but also acts as a potential ferroptosis regulator. The synthesis of squalene and its release in the endoplasmic reticulum protects the cell against lipid peroxidation, r...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378455/ https://www.ncbi.nlm.nih.gov/pubmed/37509391 http://dx.doi.org/10.3390/cancers15143731 |