The MLL–Menin Interaction is a Therapeutic Vulnerability in NUP98-rearranged AML

Chromosomal translocations involving the NUP98 locus are among the most prevalent rearrangements in pediatric acute myeloid leukemia (AML). AML with NUP98 fusions is characterized by high expression of HOXA and MEIS1 genes and is associated with poor clinical outcome. NUP98 fusion proteins are recru...

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Detalles Bibliográficos
Autores principales: Rasouli, Milad, Blair, Helen, Troester, Selina, Szoltysek, Katarzyna, Cameron, Rachel, Ashtiani, Minoo, Krippner-Heidenreich, Anja, Grebien, Florian, McGeehan, Gerard, Zwaan, C. Michel, Heidenreich, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378738/
https://www.ncbi.nlm.nih.gov/pubmed/37520776
http://dx.doi.org/10.1097/HS9.0000000000000935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378738/
https://www.ncbi.nlm.nih.gov/pubmed/37520776
http://dx.doi.org/10.1097/HS9.0000000000000935

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