Molecular Mechanism of Zinc-Dependent Oligomerization of Alzheimer’s Amyloid-β with Taiwan (D7H) Mutation

Amyloid-β (Aβ) is a peptide formed by 39–43 amino acids, heterogenous by the length of its C-terminus. Aβ constitutes a subnanomolar monomeric component of human biological fluids; however, in sporadic variants of Alzheimer’s disease (AD), it forms soluble neurotoxic oligomers and accumulates as ins...

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Detalles Bibliográficos
Autores principales: Kechko, Olga I., Adzhubei, Alexei A., Tolstova, Anna P., Indeykina, Maria I., Popov, Igor A., Zhokhov, Sergey S., Gnuchev, Nikolay V., Mitkevich, Vladimir A., Makarov, Alexander A., Kozin, Sergey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378775/
https://www.ncbi.nlm.nih.gov/pubmed/37511001
http://dx.doi.org/10.3390/ijms241411241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378775/
https://www.ncbi.nlm.nih.gov/pubmed/37511001
http://dx.doi.org/10.3390/ijms241411241

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