Cargando…

Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity

Active research of metal-containing compounds and enzymes as effective antifungal agents is currently being conducted due to the growing antifungal resistance problem. Metals are attracting special attention due to the wide variety of ligands that can be used for them, including chemically synthesiz...

Descripción completa

Detalles Bibliográficos
Autores principales: Lyagin, Ilya, Aslanli, Aysel, Domnin, Maksim, Stepanov, Nikolay, Senko, Olga, Maslova, Olga, Efremenko, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379199/
https://www.ncbi.nlm.nih.gov/pubmed/37511117
http://dx.doi.org/10.3390/ijms241411359
_version_ 1785079955581829120
author Lyagin, Ilya
Aslanli, Aysel
Domnin, Maksim
Stepanov, Nikolay
Senko, Olga
Maslova, Olga
Efremenko, Elena
author_facet Lyagin, Ilya
Aslanli, Aysel
Domnin, Maksim
Stepanov, Nikolay
Senko, Olga
Maslova, Olga
Efremenko, Elena
author_sort Lyagin, Ilya
collection PubMed
description Active research of metal-containing compounds and enzymes as effective antifungal agents is currently being conducted due to the growing antifungal resistance problem. Metals are attracting special attention due to the wide variety of ligands that can be used for them, including chemically synthesized and naturally obtained variants as a result of the so-called “green synthesis”. The main mechanism of the antifungal action of metals is the triggering of the generation and accumulation of reactive oxygen species (ROS). Further action of ROS on various biomolecules is nonspecific. Various hydrolytic enzymes (glucanases and proteases), in turn, exhibit antifungal properties by affecting the structural elements of fungal cells (cell walls, membranes), fungal quorum sensing molecules, fungal own protective agents (mycotoxins and antibiotics), and proteins responsible for the adhesion and formation of stable, highly concentrated populations in the form of biofilms. A wide substrate range of enzymes allows the use of various mechanisms of their antifungal actions. In this review, we discuss the prospects of combining two different types of antifungal agents (metals and enzymes) against mycelial fungi and yeast cells. Special attention is paid to the possible influence of metals on the activity of the enzymes and the possible effects of proteins on the antifungal activity of metal-containing compounds.
format Online
Article
Text
id pubmed-10379199
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103791992023-07-29 Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity Lyagin, Ilya Aslanli, Aysel Domnin, Maksim Stepanov, Nikolay Senko, Olga Maslova, Olga Efremenko, Elena Int J Mol Sci Review Active research of metal-containing compounds and enzymes as effective antifungal agents is currently being conducted due to the growing antifungal resistance problem. Metals are attracting special attention due to the wide variety of ligands that can be used for them, including chemically synthesized and naturally obtained variants as a result of the so-called “green synthesis”. The main mechanism of the antifungal action of metals is the triggering of the generation and accumulation of reactive oxygen species (ROS). Further action of ROS on various biomolecules is nonspecific. Various hydrolytic enzymes (glucanases and proteases), in turn, exhibit antifungal properties by affecting the structural elements of fungal cells (cell walls, membranes), fungal quorum sensing molecules, fungal own protective agents (mycotoxins and antibiotics), and proteins responsible for the adhesion and formation of stable, highly concentrated populations in the form of biofilms. A wide substrate range of enzymes allows the use of various mechanisms of their antifungal actions. In this review, we discuss the prospects of combining two different types of antifungal agents (metals and enzymes) against mycelial fungi and yeast cells. Special attention is paid to the possible influence of metals on the activity of the enzymes and the possible effects of proteins on the antifungal activity of metal-containing compounds. MDPI 2023-07-12 /pmc/articles/PMC10379199/ /pubmed/37511117 http://dx.doi.org/10.3390/ijms241411359 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lyagin, Ilya
Aslanli, Aysel
Domnin, Maksim
Stepanov, Nikolay
Senko, Olga
Maslova, Olga
Efremenko, Elena
Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity
title Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity
title_full Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity
title_fullStr Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity
title_full_unstemmed Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity
title_short Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity
title_sort metal nanomaterials and hydrolytic enzyme-based formulations for improved antifungal activity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379199/
https://www.ncbi.nlm.nih.gov/pubmed/37511117
http://dx.doi.org/10.3390/ijms241411359
work_keys_str_mv AT lyaginilya metalnanomaterialsandhydrolyticenzymebasedformulationsforimprovedantifungalactivity
AT aslanliaysel metalnanomaterialsandhydrolyticenzymebasedformulationsforimprovedantifungalactivity
AT domninmaksim metalnanomaterialsandhydrolyticenzymebasedformulationsforimprovedantifungalactivity
AT stepanovnikolay metalnanomaterialsandhydrolyticenzymebasedformulationsforimprovedantifungalactivity
AT senkoolga metalnanomaterialsandhydrolyticenzymebasedformulationsforimprovedantifungalactivity
AT maslovaolga metalnanomaterialsandhydrolyticenzymebasedformulationsforimprovedantifungalactivity
AT efremenkoelena metalnanomaterialsandhydrolyticenzymebasedformulationsforimprovedantifungalactivity