Drug-Inducible Gene Therapy Effectively Reduces Spontaneous Seizures in Kindled Rats but Creates Off-Target Side Effects in Inhibitory Neurons

Over a third of patients with temporal lobe epilepsy (TLE) are not effectively treated with current anti-seizure drugs, spurring the development of gene therapies. The injection of adeno-associated viral vectors (AAV) into the brain has been shown to be a safe and viable approach. However, to date,...

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Detalles Bibliográficos
Autores principales: Sullivan, Kyle A., Vitko, Iuliia, Blair, Kathryn, Gaykema, Ronald P., Failor, Madison J., San Pietro, Jennifer M., Dey, Deblina, Williamson, John M., Stornetta, Ruth L., Kapur, Jaideep, Perez-Reyes, Edward
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379297/
https://www.ncbi.nlm.nih.gov/pubmed/37511107
http://dx.doi.org/10.3390/ijms241411347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10379297/
https://www.ncbi.nlm.nih.gov/pubmed/37511107
http://dx.doi.org/10.3390/ijms241411347

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