Suppression of Indoxyl Sulfate Accumulation Reduces Renal Fibrosis in Sulfotransferase 1a1-Deficient Mice

Renal fibrosis is the final manifestation of chronic kidney disease (CKD); its prevention is vital for controlling CKD progression. Indoxyl sulfate (IS), a typical sulfate-conjugated uremic solute, is produced in the liver via the enzyme sulfotransferase (SULT) 1A1 and accumulates significantly duri...

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Detalles Bibliográficos
Autores principales: Hou, Huixian, Horikawa, Mai, Narita, Yuki, Jono, Hirofumi, Kakizoe, Yutaka, Izumi, Yuichiro, Kuwabara, Takashige, Mukoyama, Masashi, Saito, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380001/
https://www.ncbi.nlm.nih.gov/pubmed/37511089
http://dx.doi.org/10.3390/ijms241411329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380001/
https://www.ncbi.nlm.nih.gov/pubmed/37511089
http://dx.doi.org/10.3390/ijms241411329

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