Cargando…

Cognitive Normal Older Adults with APOE-2 Allele Show a Distinctive Functional Connectivity Pattern in Response to Cerebral Aβ Deposition

The ε2 allele of apolipoprotein E (ε2) has neuroprotective effects against beta-amyloid (Aβ) pathology in Alzheimer’s disease (AD). However, its impact on the functional connectivity and hub efficiency in cognitively normal older adults (CN) with ε2 is unclear. We investigated the functional connect...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Sheng-Min, Kang, Dong Woo, Um, Yoo Hyun, Kim, Sunghwan, Kim, Regina E. Y., Kim, Donghyeon, Lee, Chang Uk, Lim, Hyun Kook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380008/ https://www.ncbi.nlm.nih.gov/pubmed/37511008 http://dx.doi.org/10.3390/ijms241411250

Ejemplares similares

Functional Connectivity Change Associated With Apolipoprotein E Allotypes Precedes Structural Connectivity and Neurodegeneration in Cognitive Normal Older Adults Without Cerebral Aβ Deposition
por: Wang, Sheng-Min, et al.
Publicado: (2023)

Modulation of associations between education years and cortical volume in Alzheimer’s disease vulnerable brain regions by Aβ deposition and APOE ε4 carrier status in cognitively normal older adults
por: Kim, Hak-Bin, et al.
Publicado: (2023)

Olfactory Dysfunction Is Associated with Cerebral Amyloid Deposition and Cognitive Function in the Trajectory of Alzheimer’s Disease
por: Wang, Sheng-Min, et al.
Publicado: (2023)

Sex-Related Disparities in the Resting State Functional Connectivity of the Locus Coeruelus and Salience Network in Preclinical Alzheimer’s Disease
por: Um, Yoo Hyun, et al.
Publicado: (2023)

Associations Between Sub-Threshold Amyloid-β Deposition, Cortical Volume, and Cognitive Function Modulated by APOE ɛ4 Carrier Status in Cognitively Normal Older Adults
por: Kang, Dong Woo, et al.
Publicado: (2022)

Impact of APOE ε4 Carrier Status on Associations Between Subthreshold, Positive Amyloid-β Deposition, Brain Function, and Cognitive Performance in Cognitively Normal Older Adults: A Prospective Study
por: Kang, Dong Woo, et al.
Publicado: (2022)

Impact of Transcranial Direct Current Stimulation on Cognitive Function, Brain Functional Segregation, and Integration in Patients with Mild Cognitive Impairment According to Amyloid-Beta Deposition and APOE ε4-Allele: A Pilot Study
por: Kang, Dong-Woo, et al.
Publicado: (2021)

Impact of transcranial direct current stimulation on white matter microstructure integrity in mild cognitive impairment patients according to effect modifiers as risk factors for Alzheimer’s disease
por: Kang, Dong Woo, et al.
Publicado: (2023)

Depression Is Associated with the Aberration of Resting State Default Mode Network Functional Connectivity in Patients with Amyloid-Positive Mild Cognitive Impairment
por: Wang, Sheng-Min, et al.
Publicado: (2023)

Distinctive Association of the Functional Connectivity of the Posterior Cingulate Cortex on Memory Performances in Early and Late Amnestic Mild Cognitive Impairment Patients
por: Kang, Dong Woo, et al.
Publicado: (2021)

Whole Brain Voxel-Wise Analysis of Cerebral Retention of Beta-Amyloid in Cognitively Normal Older Adults Using (18)F-Florbetaben
por: Um, Yoo Hyun, et al.
Publicado: (2017)

Visual Hallucinations and Amyloid Deposition in Parkinson's Disease Dementia: A Case Report
por: Um, Yoo Hyun, et al.
Publicado: (2016)

Impact of Amyloid Burden on Regional Functional Synchronization in the Cognitively Normal Older Adults
por: Kang, Dong Woo, et al.
Publicado: (2017)

Alterations of Resting-State Locus Coeruleus Functional Connectivity After Transdermal Trigeminal Electrical Neuromodulation in Insomnia
por: Um, Yoo Hyun, et al.
Publicado: (2022)

Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals
por: Hong, Yun Jeong, et al.
Publicado: (2022)

Differences in cortical structure between cognitively normal East Asian and Caucasian older adults: a surface-based morphometry study
por: Kang, Dong Woo, et al.
Publicado: (2020)

Development of Amyloid PET Analysis Pipeline Using Deep Learning-Based Brain MRI Segmentation—A Comparative Validation Study
por: Lee, Jiyeon, et al.
Publicado: (2022)

Amyloid deposition and ApoE4 carriers in idiopathic normal pressure hydrocephalus
por: Bundo, Masahiko, et al.
Publicado: (2015)

Development of Random Forest Algorithm Based Prediction Model of Alzheimer’s Disease Using Neurodegeneration Pattern
por: Kim, JeeYoung, et al.
Publicado: (2021)

Synergistic interaction between APOE and family history of Alzheimer’s disease on cerebral amyloid deposition and glucose metabolism
por: Yi, Dahyun, et al.
Publicado: (2018)

Different Functional and Structural Characteristics between ApoA-I and ApoA-4 in Lipid-Free and Reconstituted HDL State: ApoA-4 Showed Less Anti-Atherogenic Activity
por: Yoo, Jeong-Ah, et al.
Publicado: (2015)

Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia
por: Salvadó, Gemma, et al.
Publicado: (2021)

APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study
por: Ramanan, Vijay K., et al.
Publicado: (2013)

Effects of APOE ε2 allele on basal forebrain functional connectivity in mild cognitive impairment
por: Liu, Xiaocao, et al.
Publicado: (2022)

Distinct cerebral cortical perfusion patterns in idiopathic normal‐pressure hydrocephalus
por: Kang, Kyunghun, et al.
Publicado: (2022)

Murine Gut Microbiome Association With APOE Alleles
por: Parikh, Ishita J., et al.
Publicado: (2020)

Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment
por: Joo, Soo Hyun, et al.
Publicado: (2016)

Color Image Generation from LiDAR Reflection Data by Using Selected Connection UNET
por: Kim, Hyun-Koo, et al.
Publicado: (2020)

Orexin and Alzheimer’s Disease: A New Perspective
por: Um, Yoo Hyun, et al.
Publicado: (2020)

PT570. Apathy and Intrinsic Connectivity Networks in the Amnestic Mild Cognitive Impairment
por: Lee, Chang Uk, et al.
Publicado: (2016)

Effects of Moderate Intensity Exercise on the Cortical Thickness and Subcortical Volumes of Preclinical Alzheimer’s Disease Patients: A Pilot Study
por: Um, Yoo Hyun, et al.
Publicado: (2020)

Changes in Bihemispheric Structural Connectivity Following Middle Cerebral Artery Infarction
por: Kim, Dae Hyun, et al.
Publicado: (2022)

APOE Alleles and Diet in Brain Aging and Alzheimer’s Disease
por: Yassine, Hussein N., et al.
Publicado: (2020)

Erratum to “Prediction of Treatment Response to Donepezil using Automated Hippocampal Subfields Volumes Segmentation in Patients with Mild Alzheimer's Disease”
por: Um, Yoo Hyun, et al.
Publicado: (2017)

Prediction of Treatment Response to Donepezil using Automated Hippocampal Subfields Volumes Segmentation in Patients with Mild Alzheimer's Disease
por: Um, Yoo Hyun, et al.
Publicado: (2017)

LCAT, ApoD, and ApoA1 Expression and Review of Cholesterol Deposition in the Cornea
por: Flores, Rhonda, et al.
Publicado: (2019)

Differential Risk of Incident Fractures Depending on Intensity and Frequency of Physical Activity According to Cognitive Status: A Nationwide Longitudinal Study
por: Kang, Dong Woo, et al.
Publicado: (2020)

Deep Learning-Based Segmentation to Establish East Asian Normative Volumes Using Multisite Structural MRI
por: Kim, Regina E. Y., et al.
Publicado: (2020)

Brain ApoA-I, ApoJ and ApoE Immunodetection in Cerebral Amyloid Angiopathy
por: Camacho, Jessica, et al.
Publicado: (2019)

Polygenic Risk Score Analysis of Alzheimer’s Disease in Cases without APOE4 or APOE2 Alleles
por: Escott-Price, V., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_pgstdlp9pd7mbldrlpfpdqvn94