Protective Effect of Water-Soluble Acacetin Prodrug on APAP-Induced Acute Liver Injury Is Associated with Upregulation of PPARγ and Alleviation of ER Stress

A water-soluble acacetin prodrug has been synthesized and reported by our group previously. Acetaminophen (APAP) overdose is a leading cause of acute liver injury. We found that subcutaneous injection of acacetin prodrug (5, 10, 20 mg/kg) decreased serum ALT, AST, and ALP, corrected the abnormal MDA...

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Detalles Bibliográficos
Autores principales: Miao, Jiaen, Yao, Shujun, Sun, Hao, Jiang, Zhe, Gao, Zhe, Xu, Jia, Chen, Kuihao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380069/
https://www.ncbi.nlm.nih.gov/pubmed/37511082
http://dx.doi.org/10.3390/ijms241411320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380069/
https://www.ncbi.nlm.nih.gov/pubmed/37511082
http://dx.doi.org/10.3390/ijms241411320

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