DNA Damage Repair Pathways in Prostate Cancer: A Narrative Review of Molecular Mechanisms, Emerging Biomarkers and Therapeutic Targets in Precision Oncology

Prostate cancer (PCa) has a distinct molecular signature, including characteristic chromosomal translocations, gene deletions and defective DNA damage repair mechanisms. One crucial pathway involved is homologous recombination deficiency (HRD) and it is found in almost 20% of metastatic castrate-res...

Descripción completa

Detalles Bibliográficos
Autores principales: Grypari, Ioanna-Maria, Tzelepi, Vasiliki, Gyftopoulos, Kostis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380086/
https://www.ncbi.nlm.nih.gov/pubmed/37511177
http://dx.doi.org/10.3390/ijms241411418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380086/
https://www.ncbi.nlm.nih.gov/pubmed/37511177
http://dx.doi.org/10.3390/ijms241411418

Ejemplares similares