Cargando…

DNA Damage Repair Pathways in Prostate Cancer: A Narrative Review of Molecular Mechanisms, Emerging Biomarkers and Therapeutic Targets in Precision Oncology

Prostate cancer (PCa) has a distinct molecular signature, including characteristic chromosomal translocations, gene deletions and defective DNA damage repair mechanisms. One crucial pathway involved is homologous recombination deficiency (HRD) and it is found in almost 20% of metastatic castrate-res...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grypari, Ioanna-Maria, Tzelepi, Vasiliki, Gyftopoulos, Kostis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10380086/ https://www.ncbi.nlm.nih.gov/pubmed/37511177 http://dx.doi.org/10.3390/ijms241411418

Ejemplares similares

Radical or Not-So-Radical Prostatectomy: Do Surgical Margins Matter?
por: Grypari, Ioanna Maria, et al.
Publicado: (2021)

Contemporary Grading of Prostate Cancer: The Impact of Grading Criteria and the Significance of the Amount of Intraductal Carcinoma
por: Tzelepi, Vasiliki, et al.
Publicado: (2021)

The protein arginine methyltransferases (PRMTs) PRMT1 and CARM1 as candidate epigenetic drivers in prostate cancer progression
por: Grypari, Ioanna Maria, et al.
Publicado: (2021)

The role of the endothelin axis in promoting epithelial to mesenchymal transition and lymph node metastasis in prostate adenocarcinoma
por: Papanikolaou, Sophia, et al.
Publicado: (2017)

Therapeutic Targeting of DNA Damage Repair in the Era of Precision Oncology and Immune Checkpoint Inhibitors
por: Clark, Curtis A., et al.
Publicado: (2022)

Radical Prostatectomy and Anatomical Controversies: The Urethral Sphincter and the Elusive Continence Mechanisms
por: Gyftopoulos, Kostis
Publicado: (2023)

Cell Plasticity and Prostate Cancer: The Role of Epithelial–Mesenchymal Transition in Tumor Progression, Invasion, Metastasis and Cancer Therapy Resistance
por: Papanikolaou, Sofia, et al.
Publicado: (2021)

The efficacy and safety of topical EMLA cream application for minor surgery of the adult penis
por: Gyftopoulos, Kostis I.
Publicado: (2012)

Meatal stenosis after surgical correction of short frenulum: Is the “pull-and-burn” method the way to go?
por: Gyftopoulos, Kostis I.
Publicado: (2018)

Prostate Cancer: Pathophysiology, Pathology and Therapy
por: Tzelepi, Vasiliki
Publicado: (2022)

The expression of vascular endothelial growth factor-C correlates with lymphatic microvessel density and lymph node metastasis in prostate carcinoma: An immunohistochemical study
por: Kostis, Gyftopoulos, et al.
Publicado: (2014)

A Narrative Review of Implementing Precision Oncology in Metastatic Castration-Resistant Prostate Cancer in Emerging Countries
por: Bazarbashi, Shouki, et al.
Publicado: (2021)

Epithelial-to-Mesenchymal Transition in Metastasis: Focus on Laryngeal Carcinoma
por: Goulioumis, Anastasios, et al.
Publicado: (2022)

The Eustachian Tube Dysfunction in Children: Anatomical Considerations and Current Trends in Invasive Therapeutic Approaches
por: Goulioumis, Anastasios K, et al.
Publicado: (2022)

Genetic aberrations in DNA repair pathways: a cornerstone of precision oncology in prostate cancer
por: Lozano, Rebeca, et al.
Publicado: (2020)

Biomarkers in the Era of Precision Oncology
por: Baxevanis, Constantin N.
Publicado: (2023)

An Emerging Role for Radiation Oncology in Precision Oncology
por: Goyal, Sharad, et al.
Publicado: (2016)

Embryological, anatomical and clinical considerations on pleuroperitoneal communication
por: Chatzigrigoriadis, Christodoulos, et al.
Publicado: (2023)

Editorial: Exploiting DNA Damage Response in the Era of Precision Oncology
por: Zimmer, Yitzhak, et al.
Publicado: (2020)

DNA-protein biomarkers for immunotherapy in the era of precision oncology
por: Kim, Binnari, et al.
Publicado: (2021)

Cribriform Patterned Lesions in the Prostate Gland with Emphasis on Differential Diagnosis and Clinical Significance
por: Destouni, Maria, et al.
Publicado: (2022)

Comprehensive Analysis of DNA Methyltransferases Expression in Primary and Relapsed Ovarian Carcinoma
por: Papakonstantinou, Efthymia, et al.
Publicado: (2023)

Epithelial–Mesenchymal Transition Signaling and Prostate Cancer Stem Cells: Emerging Biomarkers and Opportunities for Precision Therapeutics
por: Chaves, Luiz Paulo, et al.
Publicado: (2021)

Exploiting DNA Damage Repair in Precision Cancer Therapy: BRCA1 as a Prime Therapeutic Target
por: Raimundo, Liliana, et al.
Publicado: (2021)

Germline Variants in DNA Damage Repair Genes: An Emerging Role in the Era of Precision Medicine in Pancreatic Adenocarcinoma
por: Shoucair, Sami, et al.
Publicado: (2021)

Management of Advanced Prostate Cancer in the Precision Oncology Era
por: Gillette, Claire M., et al.
Publicado: (2023)

Racial disparity in the genomics of precision oncology of prostate cancer
por: Le, Tu, et al.
Publicado: (2023)

Current and upcoming radionuclide therapies in the direction of precision oncology: A narrative review
por: Shah, Hina J., et al.
Publicado: (2023)

The emerging role of RNAs in DNA damage repair
por: Hawley, Ben R, et al.
Publicado: (2017)

The Current Status of DNA-Repair-Directed Precision Oncology Strategies in Epithelial Ovarian Cancers
por: Tang, Hiu, et al.
Publicado: (2023)

Artificial intelligence, molecular subtyping, biomarkers, and precision oncology
por: Shen, John Paul
Publicado: (2021)

Identification of DNA Damage Repair-Associated Prognostic Biomarkers for Prostate Cancer Using Transcriptomic Data Analysis
por: Teng, Pai-Chi, et al.
Publicado: (2021)

Histone and DNA Methylation as Epigenetic Regulators of DNA Damage Repair in Gastric Cancer and Emerging Therapeutic Opportunities
por: De Marco, Katia, et al.
Publicado: (2023)

Lineage Plasticity and Stemness Phenotypes in Prostate Cancer: Harnessing the Power of Integrated “Omics” Approaches to Explore Measurable Metrics
por: Logotheti, Souzana, et al.
Publicado: (2023)

Therapeutics for paediatric oncological emergencies
por: Leung, Karen Ka Yan, et al.
Publicado: (2021)

Roles of DNA damage repair and precise targeted therapy in renal cancer (Review)
por: Lai, Yongchang, et al.
Publicado: (2022)

Prostate Cancer in Transplant Receivers—A Narrative Review on Oncological Outcomes
por: Hanusz, Karolina, et al.
Publicado: (2023)

Role of artificial intelligence in oncologic emergencies: a narrative review
por: Fanni, Salvatore Claudio, et al.
Publicado: (2023)

Evidence‐Based Development and Clinical Use of Precision Oncology Therapeutics
por: Comment, Leah A., et al.
Publicado: (2020)

Novel directions of precision oncology: circulating microbial DNA emerging in cancer-microbiome areas
por: You, Liting, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lqipvb5sn3rl262gm4rl4lurvf